Accuracy of intraoperative imprint cytology of sentinel lymph nodes in breast cancer - 18/08/11
Corresponding author. Tel.: +1-206-215-6410; fax: +1-206-215-6401.Abstract |
Background |
In breast cancer treatment, immediate completion of axillary lymph node dissection (ALND) can be performed if the intraoperative sentinel lymph node (SLN) examination is positive. This study evaluates the accuracy of intraoperative imprint cytology (IC) for detecting SLN metastases.
Methods |
Pathology reports from 385 SLN biopsy examinations were reviewed retrospectively. The SLNs were serially sectioned perpendicular to the long axis and IC was performed intraoperatively. The SLNs then were formalin-fixed for permanent sections. Final pathology was compared with the intraoperative IC results.
Results |
The sensitivities for IC detection of N0(i+) (n = 36), N1mi (n = 24), and N1a-3a (n = 65) metastases were 0%, 4%, and 74%, respectively. The specificity was 100%.
Conclusions |
Final pathology identified 89 (23%) patients with N1 or greater disease. IC allowed 49 (55%) of these patients to undergo synchronous completion of ALND. No unnecessary completion ALNDs were performed. The sensitivity of IC decreased with decreasing size of the metastasis.
El texto completo de este artículo está disponible en PDF.Keywords : Imprint cytology, Touch preparation, Sentinel lymph node, Sentinel lymph node biopsy, Breast cancer
Esquema
Vol 192 - N° 4
P. 516-519 - octobre 2006 Regresar al número
Artículo precedente
- Intraoperative digital specimen mammography: prompt image review speeds surgery
- Cary S. Kaufman, Barbara A. Bachman, Leslie Jacobson, Lauren B. Kaufman, Carol Mahon, Laura Gambrell
- Biologic significance of false-positive magnetic resonance imaging enhancement in the setting of ductal carcinoma in situ
- Anjali S. Kumar, Daniel F. Chen, Alfred Au, Yunn-Yi Chen, Jessica Leung, Elisabeth R. Garwood, Jessica Gibbs, Nola Hylton, Laura J. Esserman
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
¿Ya suscrito a @@106933@@ revista ?