Cytokines and chemokines orchestrate atopic skin inflammation - 17/08/11
, Martin Steinhoff, MD, PhD b, Thomas Ruzicka, MD a, Donald Y.M. Leung, MD, PhD c
Reprint requests: Bernhard Homey, MD, Department of Dermatology, Heinrich-Heine-University, Moorenstr. 5, Düsseldorf 40225, Germany.Düsseldorf and Münster, Germany, and Denver, Colo
Abstract |
Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease. The pathophysiology of AD includes disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD.
El texto completo de este artículo está disponible en PDF.Key words : Atopic dermatitis, immunity, pruritus, lymphocyte, trafficking
Abbreviations used : AD, CD40L, CLA, DC, IL-31RA, LC, OSMR, TSLP
Esquema
| B. H. and T. R. are supported by grants of 5th frame work of the European Union and the German Research Foundation, the German Research Foundation (SFB 503). M. S. was supported by grants from the German Research Foundation (STE 1014, SFB 293), the Federal Ministry of Education and Research (IZKF), and CE.R.I.E.S. Paris. Disclosure of potential conflict of interest: B. Homey has received grants/research support from the German Research Foundation and the German Cancer Foundation. D. Y. M. Leung has served on the speakers’ bureau for Novartis and Astellas. The rest of the authors have declared that they have no conflict of interest. |
Vol 118 - N° 1
P. 178-189 - juillet 2006 Regresar al número
Artículo precedente
- Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects
- Scott H. Sicherer, Donald Y.M. Leung
- Role of vasculature in atopic dermatitis
- Martin Steinhoff, Antje Steinhoff, Bernhard Homey, Thomas A. Luger, Stefan W. Schneider
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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