Is high-grade prostatic intraepithelial neoplasia on needle biopsy different in an Asian population: A clinicopathologic study performed in Singapore - 16/08/11
, Hong Wui Tan a, Yen Tan a, Chay Ngee Lim a, Christopher Cheng b, Jonathan I. Epstein c
Reprint requests: Puay Hoon Tan, M.D., Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608 Singapore.Abstract |
Objectives |
To evaluate the incidence, pathologic findings, and follow-up of high-grade prostatic intraepithelial neoplasia (HGPIN) in a series of prostate core biopsies from Singaporean men.
Methods |
We studied isolated HGPIN diagnosed on prostate core biopsies and the incidence of cancer discovered in men who had undergone repeat biopsies from 1999 to 2003 at the Department of Pathology, Singapore General Hospital.
Results |
Of 1219 men undergoing prostate needle biopsy, 56 (4.6%) had isolated HGPIN. Most cases affected a single prostate core (44 cases, 78.6%). Twenty-nine men (51.8%) underwent repeat biopsies. Cancer was discovered in 7 (24.1%) of the 29 men within two repeat biopsies.
Conclusions |
The incidence of isolated HGPIN on prostate needle core biopsies in Asian men, as well as the likelihood of subsequent cancer detection, are comparable to the rates reported for Western populations. The relatively low yield of cancer detection on repeat biopsy supports the need to re-evaluate recommendations for rebiopsy strategies.
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Vol 68 - N° 4
P. 800-803 - octobre 2006 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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