Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III - 15/08/11
, Bengt Björkstén, MD, PhD b, Javier Mallol, MD c, Stephen Montefort, MD, PhD d, Erika von Mutius, MD, MSc eInternational Study of Asthma and Allergies in Childhood Phase III Study Group
Reprint requests: Neil Pearce, PhD, DSc, Centre for Public Health Research, Massey University, Wellington Campus, Private Box 756, Wellington, New Zealand.Abstract |
Background |
Phase III of the International Study of Asthma and Allergies in Childhood measured the global prevalence of symptoms of asthma, rhinoconjunctivitis, and eczema in children.
Objective |
To investigate the associations between the use of antibiotics in the first year of life and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old.
Methods |
Parents or guardians of children 6 and 7 years old completed written questionnaires on current symptoms and possible risk factors. Prevalence odds ratios (ORs) were estimated by using logistic regression.
Results |
A total of 193,412 children from 71 centers in 29 countries participated. Reported use of antibiotics in the first year of life was associated with an increased risk of current asthma symptoms (wheezing in the previous 12 months) with an OR (adjusted for sex, region of the world, language, and per capita gross national income) of 1.96 (95% CI, 1.85-2.07); this fell to 1.70 (1.60-1.80) when adjusted for other risk factors for asthma. Similar associations were observed for severe asthma symptoms (OR, 1.82; 95% CI, 1.67-1.98), and asthma ever (OR, 1.94; 95% CI, 1.83-2.06). Use of antibiotics in the first year of life was also associated, but less strongly, with increased risks of current symptoms of rhinoconjunctivitis (OR, 1.56; 95% CI, 1.46-1.66) and eczema (OR, 1.58; 95% CI, 1.33-1.51).
Conclusion |
There is an association between antibiotic use in the first year of life and current symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old. Further research is required to determine whether the observed associations are causal or are a result of confounding by indication or reverse causation.
El texto completo de este artículo está disponible en PDF.Key words : Antibiotics, ISAAC, asthma, rhinoconjunctivitis, eczema
Abbreviations used : ISAAC, OR
Esquema
| Disclosure of potential conflict of interest: S. Foliaki has received research support from the New Zealand Health Research Council and the Center for Public Health Research, Massey University. E. von Mutius has consulted for GlaxoSmithKline, UCB, and ProtectImmun and has received research support from Airsonett. The rest of the authors have declared that they have no conflict of interest. |
Vol 124 - N° 5
P. 982-989 - novembre 2009 Regresar al número
Artículo precedente
- Long-term pathologic consequences of acute irritant-induced asthma
- Naoya Takeda, Karim Maghni, Sylvie Daigle, Jocelyne L’Archevêque, Lucero Castellanos, Wisam Al-Ramli, Jean-Luc Malo, Qutayba Hamid
- Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma
- Anne M. Fitzpatrick, Lou Ann S. Brown, Fernando Holguin, W. Gerald Teague, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program ∗
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
¿Ya suscrito a @@106933@@ revista ?