The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-⍺-1,3-galactose - 11/08/11
, Hayley R. James, BS a, , Libby A. Kelly, MD a, Shawna L. Pochan, CNM, MPH a, Lisa J. Workman, BA a, Matthew S. Perzanowski, PhD, MPH b, Katherine M. Kocan, PhD c, John V. Fahy, MD d, Lucy W. Nganga, MD e, Eva Ronmark, PhD f, Philip J. Cooper, MB BS, PhD g, h, Thomas A.E. Platts-Mills, FRS a, ⁎ 
Reprint requests: Thomas A. E. Platts-Mills, MD, PhD, Allergy Division, University of Virginia Health System, PO Box 801355, Charlottesville, VA 22908.Abstract |
Background |
In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-⍺-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies.
Objectives |
We sought to investigate possible causes of this IgE antibody response, focusing on evidence related to tick bites, which are common in the region where these reactions occur.
Methods |
Serum assays were carried out with biotinylated proteins and extracts bound to a streptavidin ImmunoCAP.
Results |
Prospective studies on IgE antibodies in 3 subjects after tick bites showed an increase in levels of IgE to alpha-gal of 20-fold or greater. Other evidence included (1) a strong correlation between histories of tick bites and levels of IgE to alpha-gal (χ2 = 26.8, P < .001), (2) evidence that these IgE antibodies are common in areas where the tick Amblyomma americanum is common, and (3) a significant correlation between IgE antibodies to alpha-gal and IgE antibodies to proteins derived from A americanum (rs = 0.75, P < .001).
Conclusion |
The results presented here provide evidence that tick bites are a cause, possibly the only cause, of IgE specific for alpha-gal in this area of the United States. Both the number of subjects becoming sensitized and the titer of IgE antibodies to alpha-gal are striking. Here we report the first example of a response to an ectoparasite giving rise to an important form of food allergy.
El texto completo de este artículo está disponible en PDF.Key words : Ticks, anaphylaxis, oligosaccharide, alpha-gal, IgE antibody to CCD
Abbreviation used : Alpha-gal
Esquema
| Supported by National Institutes of Health grant RO1 AI-20565, AI-AADCRC-U19-070364, K08 AI085190, R21 AI087985, and the Wellcome Trust 072405/Z/03/Z (to P. J. C.). |
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| Disclosure of potential conflict of interest: S. P. Commins is a volunteer committee member for the American Association of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma & Immunology and is an author for Up-to-Date. M. S. Perzanowski receives research support from the National Institutes of Health (NIH) and is a member of the AAAAI. J. V. Fahy receives research support from the NIH. P. J. Cooper receives research support from Wellcome Trust. T. A. E. Platts-Mills receives research support from Phadia and the NIH and has a patent on an assay. The rest of the authors have declared that they have no conflict of interest. |
Vol 127 - N° 5
P. 1286 - mai 2011 Regresar al número
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