Role of Dermal-Epidermal Basement Membrane Zone in Skin, Cancer, and Developmental Disorders - 05/08/11

Doi : 10.1016/j.det.2009.10.001

Myung S. Ko, BA ^a, M. Peter Marinkovich, MD ^a,^b,^c,^⁎
^a Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
^b Department of Dermatology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, Stanford, CA 94305, USA
^c Dermatology Service, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA

Corresponding author. Department of Dermatology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, Stanford, CA 94305.

Resumen

The dermal-epidermal basement membrane zone is an important epithelial and stromal interface, consisting of an intricately organized collection of intracellular, transmembrane, and extracellular matrix proteins. The basement membrane zone has several main functions including acting as a permeability barrier, forming an adhesive interface between epithelial cells and the underlying matrix, and controlling cellular organization and differentiation. This article identifies key molecular players of the dermal-epidermal membrane zone, and highlights recent research studies that have identified structural and functional roles of these components in the context of various blistering, neoplastic, and developmental syndromes.

El texto completo de este artículo está disponible en PDF.

Keywords : Basement membrane zone, Laminin, Integrin, Keratin, Collagen, Epidermolysis bullosa, Blistering disorder