The status of humoral immunity in occult HBV infection in south-eastern Iranian patients - 20/04/11
, Ali Akbar Pourfathollah c, Abdollah Jafarzadeh a, b, Gholamhossein Hassanshahi a, b, Ali Shamizadeh d, Behzad Nasiri Ahmadabadi b, Derek Kennedy e
Corresponding author. Tel.: +983915234003-5; fax: +983915225209.Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 6 |
| Iconografías | 3 |
| Vídeos | 0 |
| Otros | 0 |
Summary |
Background |
Occult hepatitis B infection (OBI) is characterized as a form of hepatitis in which, despite of absence of detectable HBsAg, HBV-DNA is present in patient’s peripheral blood. The aim of this study was to investigate components of humoral immunity during OBI as a possible measure of how patients respond to Hepatitis B viral infections.
Material and methods |
In this study, HBsAg-/anti-HBc+/HBV-DNA+ samples were assigned as OBI cases and SRID techniques were performed to measure levels of circulating antibodies (IgG, IgM and IgA) as well as C3, C4. In addition, complement system function was assessed by CH50.
Results |
Our results showed that the serum levels of IgG and C4 were significantly lower in OBI patients, while IgM and C3 were higher in patients when compared to healthy controls. Serum levels of IgA and CH50 were not significantly different between OBI patients and controls.
Discussion |
Based on these results, it could be concluded that although OBI patients produced elevated levels of IgM there may be a problem converting and progressing this response to generate enough IgG to overcome HBV infection.
El texto completo de este artículo está disponible en PDF.Esquema
Vol 35 - N° 4
P. 309-314 - avril 2011 Regresar al número
Artículo precedente
- Evaluation of nitrite/nitrate levels in relation to oxidative stress parameters in liver cirrhosis
- Yusuf Ergün, Ergül Belge Kurutaş, Burhan Özdil, Ramazan Güneşaçar, Yılmaz Ergün
- Clostridium difficile infection in patients with ulcerative colitis: Investigations of risk factors and efficacy of antibiotics for steroid refractory patients
- Takashi Kaneko, Reikei Matsuda, Masataka Taguri, Masahiko Inamori, Asami Ogura, Eiji Miyajima, Katsuaki Tanaka, Shin Maeda, Hideaki Kimura, Reiko Kunisaki
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?