Pathological bands formed between two surfaces within the body cavity as a result of surgical incision are termed as adhesions. Almost every abdominal, pelvis, peritoneal and thoracic surgery result in post-operative adhesions, the stages of forming thin film of connective tissue to thick fibrous adhesive bands is still unclear. Clinically silent post-operative adhesion result in reduced quality of life by having chronic abdominal pain, small bowel obstruction and even infertility leading to frequent hospitalizations. Planning a preventive strategy for the same requires detailed overview of different types of adhesions and time period required for developing certain forms of adhesion. Despite enormous clinical reviews and investigations there is no literature suggesting views and hypothesis of different stages of adhesion formation, this study will focus on various biomarkers, and mechanisms for defining a picture of different stages of adhesions. By understanding these stages and the underlying mechanism, targeted strategies for prevention and treatment can be made which ultimately help in improving patient outcomes and reduces the burden on healthcare systems. The study provides evidence for planning future studies on the basis of different stages of adhesion in pathological healing among subjects undergoing abdominal surgery to prevent them during the initial stages.