Jin-Seok Lee, PhD a, b, Yujin Choi, KMD c, Jin-Yong Joung, KMD, PhD b, d, Chang-Gue Son, KMD, PhD b, c, ⁎ 
a Institute of Bioscience & Integrative Medicine, Daejeon University, Daehak-ro 75, Daejeon 35235, Republic of Korea
b Department of Internal Medicine, College of Korean Medicine, Se-Myung University, Jecheon-si 27136, Republic of Korea
c Department of Korean Medicine, Korean Medical College of Daejeon University, Daehak-ro 62, Dong-gu, Daejeon 34520, Republic of Korea
d Department of Internal Medicine, Daejeon Good-morning Oriental Hospital, 21, Dunsan-ro 123beon-gil, Seo-gu, Daejeon 35240, Republic of Korea