Association of Sedentary Lifestyle with Risk of Acute and Post-Acute COVID-19 Sequelae: A Retrospective Cohort Study - 10/02/25
, Stephen Heung-Sang Wong, PhD a
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Abstract |
Background |
Evidence suggests that coronavirus disease 2019 (COVID-19) survivors could experience COVID-19 sequelae. Although various risk factors for COVID-19 sequelae have been identified, little is known about whether a sedentary lifestyle is an independent risk factor.
Methods |
In this retrospective cohort study, 4850 participants self-reported their COVID-19 sequelae symptoms between June and August 2022. A sedentary lifestyle included physical inactivity (<150 min/week of moderate-to-vigorous intensity physical activity) and prolonged sedentary behavior (≥10 h/day) before the fifth COVID-19 wave was recorded. Logistic regression analysis was performed to determine the relationships between sedentary lifestyle and risk of acute and post-acute (lasting ≥2 months) COVID-19 sequelae.
Results |
A total of 1443 COVID-19 survivors and 2962 non-COVID-19 controls were included. Of the COVID-19 survivors, >80% and >40% self-reported acute and post-acute COVID-19 sequelae, respectively. In the post-acute phase, COVID-19 survivors who were physically inactive had a 37% lower risk of insomnia, whereas those with prolonged sedentary behavior had 25%, 67%, and 117% higher risks of at least one symptom, dizziness, and “pins and needles” sensation, respectively. For the acute phase, prolonged sedentary behavior was associated with a higher risk of fatigue, “brain fog,” dyspnea, muscle pain, joint pain, dizziness, and “pins and needles” sensation. Notably, sedentary behavior, rather than physical inactivity, was correlated with a higher risk of severe post-COVID-19 sequelae in both acute and post-acute phases.
Conclusions |
Prolonged sedentary behavior was independently associated with a higher risk of both acute and post-acute COVID-19 sequelae, whereas physical inactivity played contradictory roles in COVID-19 sequelae.
El texto completo de este artículo está disponible en PDF.Keywords : COVID-19 sequelae, Long COVID, Omicron variant, Physical inactivity, Post-COVID conditions, Sedentary behaviors, Sedentary lifestyle
Esquema
| Funding: This work was supported by the Research Grants Council (RGC) General Research Fund (GRF), Hong Kong [14608521]; and University Grants Committee, The Chinese University of Hong Kong, Hong Kong [3110155]. CZ was supported by the Research Fellowship Scheme, The Chinese University of Hong Kong. |
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| Conflicts of Interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
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| Authorship: All authors had access to the data. SW and XC conceptualized the study. CZ, WH, FS, and XC were responsible for protocol development and data collection. MW and PS were responsible for the analysis and interpretation of data. CZ and XC contributed to the first draft of the manuscript. SW was responsible for study and team supervision. All authors read and approved the final manuscript. CZ: Data curation, Investigation, Methodology, Writing — original draft, Writing — review & editing. WY-JH: Data curation, Formal analysis, Methodology, Resources, Validation, Writing — review & editing. F-HS: Data curation, Investigation, Methodology, Resources, Writing — review & editing. MC-SW: Formal analysis, Investigation, Software, Writing — review & editing. PM-FS: Formal analysis, Investigation, Writing — review & editing. X-KC: Data curation, Supervision, Investigation, Methodology, Writing — original draft, Writing — review & editing. SH-SW: Conceptualization, Supervision, Writing — review & editing. |
Vol 138 - N° 2
P. 298 - février 2025 Regresar al número
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