Physical Health and Mental Fatigue Disability Associated with Long COVID: Baseline Results from a US Nationwide Cohort - 10/02/25
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Abstract |
Background |
Persistent symptoms after severe acute respiratory disease coronavirus 2 (SARS-COV-2; long COVID) occur in 10%-55% of individuals, but the impact on daily functioning and disability remains unquantified.
Methods |
To characterize disability associated with long COVID, we analyzed baseline data from an online, US-based cohort study. Adult participants included those reporting a history of COVID-19 (n = 8874) or never having COVID-19 (n = 633) without prior disability. The main outcomes were self-reported physical mobility, instrumental activities of daily living (IADL), and mental fatigue disability, assessed by measuring 5 disability components: difficulty walking a quarter mile or climbing 10 stairs (mobility), difficulty doing light or heavy housework (IADL), and Wood Mental Fatigue Inventory score (mental fatigue).
Results |
Of 7926 participants with long COVID, 65% were classified with at least one disability, as compared with 6% and 14% for resolved COVID and no COVID, respectively. Additionally, 22% were classified as disabled in all 3 categories. Age, prior comorbidity, increased body mass index, female sex, COVID-19 hospitalization, non-white/multi-race were associated with higher disability burden. Dizziness and heavy limbs at infection were associated with disability regardless of hospitalization. Dyspnea and tremors were associated with disability in non-hospitalized individuals. Vaccination was protective against disability.
Conclusions |
We observed a high burden of new disability associated with long COVID, which has serious implications for individual and societal health. Longitudinal evaluation of COVID-19 patients is necessary to identify patterns of recovery and treatment options.
El texto completo de este artículo está disponible en PDF.Keywords : Long COVID, Mental fatigue, Physical disability
Esquema
| Funding: This study was supported by the Johns Hopkins University COVID-19 Research Response Program and in part by the Johns Hopkins University Center for AIDS Research (P30AI094189), which is supported by the following National Institutes of Health (NIH) Co-Funding and Participating Institutes and Centers: National Institute of Allergy and Infectious Diseases (NIAID), National Cancer Institute, National Institute of Child Health and Human Development (NICHD), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Drug Abuse (NIDA), National Institute on Aging, National Institute of General Medical Sciences (NIGMS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Minority Health and Health Disparities (NIMHD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. |
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| Conflicts of Interest: The authors have no conflicts of interest to declare. |
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| Authorship: BL, SHM, and PD had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Concept and Design: BL, SHM, PD; Statistical Analysis: BL, ZN, KY; Acquisition, analysis or interpretation of data: All authors; Drafting of the manuscript: BL, EW, SHM, PD; Critical revision of the manuscript for important intellectual content: All authors; Administrative, technical or material support: EW, CV, ZN. |
Vol 138 - N° 2
P. 287 - février 2025 Regresar al número
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