A diverse hidradenitis suppurativa cohort: A retrospective cross-sectional study of 13,130 patients from a large US health care system database from 1995 to 2022 - 05/12/24

Doi : 10.1016/j.jaad.2024.10.073

Kelly Z. Young, MD, PhD ^a, Ian Loveless, MS ^a,^b,^c, Wan-Ting K. Su, PhD ^b,^c,^d, Jesse Veenstra, MD, PhD ^a,^d,^e,^f,^g, Congcong Yin, MD, PhD ^a,^e, Peter Dimitrion, MS ^a,^e,^h, Rachel Krevh, MD ^a,^e, Li Zhou, MD, MS ^a,^d,^e,^f,^g,^i,^j, Ruicong She, MS ^b, Mingming Pan, MS ^b, Albert M. Levin, PhD ^b,^c,^d, Albert Young, MD ^g, Eglal Samir, BS ^a, Andrea Dai, BS ^a, James Ge, BS ^a, Richard H. Huggins, MD ^d,^f,^g, Cristina de Guzman Strong, PhD ^a,^d,^e,^f,^g, Henry W. Lim, MD ^d,^f,^g, David M. Ozog, MD ^d,^f,^g, Iltefat Hamzavi, MD ^g,^⁎ , Indra Adrianto, PhD ^a,^b,^d,^e,^f,^⁎ , Qing-Sheng Mi, MD, PhD ^a,^d,^e,^f,^g,^h,^i,^j,^⁎
^a Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan
^b Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan
^c Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan
^d Henry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan
^e Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan
^f Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan
^g Department of Dermatology, Henry Ford Health, Detroit, Michigan
^h Cancer Biology Graduate Program, School of Medicine, Wayne State University, Detroit, Michigan
ⁱ Department of Biochemistry, Microbiology, and Immunology, School of Medicine, Wayne State University, Detroit, Michigan
^j Department of Internal Medicine, Henry Ford Health, Detroit, Michigan

^∗Correspondence to: Iltefat Hamzavi, MD, Department of Dermatology, Henry Ford Health, 3031 W Grand Blvd, Detroit, MI 48202.xxxxxxXxxXx^∗Indra Adrianto, PhD, Department of Public Health Sciences, Henry Ford Health, 1 Ford Place, Rm 3E, Detroit, MI 48202.Department of Public Health Sciences, Henry Ford Health1 Ford Place, Rm 3EDetroitMI48202^∗Qing-Sheng Mi, MD, PhD, Department of Dermatology, Henry Ford Health, 1 Ford Place, Rm 1D31, Detroit, MI 48202.Department of Dermatology, Henry Ford Health1 Ford Place, Rm 1D31DetroitMI48202

En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Thursday 05 December 2024

Abstract

Background

Most epidemiological studies of hidradenitis suppurativa (HS) have described homogeneous patient populations.

Objective

To characterize demographics, modifiable health behaviors, and comorbidities of HS patients within a diverse cohort.

Methods

A retrospective cross-sectional study of 13,130 HS patients within a health care system was conducted.

Results

A female sex bias of ∼3:1 in all racial/ethnic subgroups was observed. Black/African American (AA) patients had a lower age at HS diagnosis than White patients (37.1 years vs 39.4 years, P < .001). A higher proportion of Black/AA females than White females with HS had body mass index in the obese range (69.9% vs 56.5%; P = .03). In contrast, fewer Black/AA males with HS had a body mass index in the obese range compared to White males (51.4% vs 61.0%; P < .001). More Black/AA patients than White patients with HS had congestive heart failure (odds ratio (OR) = 2.10, confidence interval (CI) = 1.19-3.78; P < .05), chronic pulmonary disease (OR = 1.34; CI = 1.02-1.78; P < .05), diabetes with chronic complication (OR = 1.73; CI = 1.16-2.60; P < .05), renal disease (OR = 2.66; CI = 1.67-4.34; P < .05), and Charlson comorbidity index score ≥4 (OR = 1.67; CI = 1.09-2.58; P < .05). Furthermore, male patients were more likely than female patients to have renal disease (OR = 2.62; CI = 1.66-4.14; P < .05).

Limitations

A single-center study.

Conclusion

Subgroups of HS patients had significant differences in demographics, risk factors, and comorbid conditions.

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Key words : comorbidity, demographics, epidemiology, hidradenitis suppurativa, risk factors, sex bias

Abbreviations used : AA, BMI, CCI, CI, EHR, HS, OR, SD

Esquema

Introduction

Methods

Study setting and data collection

Statistical analysis

Results

Patient characteristics

Comorbid conditions

Discussion

	Drs Young, Veenstra and Authors Loveless, Su are equally contributed to this study.
	Funding sources: Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, United States, under Award Number R01AR083553, R01AR078688, R21AR079089, and R33AR076803 to Adrianto and Mi and Henry Ford Immunology Program Research Support to Zhou, Adrianto, and Mi. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
	Patient consent: Not applicable, a minimal risk retrospective chart review in which no patient interaction will occur.
	IRB approval status: Reviewed and approved by Henry Ford Health IRB; approval #12826.