Investigating the role of dietary glycemic factors and antioxidant capacity, metabolic status, and oxidative stress in seborrheic dermatitis: A case-control study - 05/12/24

Doi : 10.1016/j.jaad.2024.10.078

Yavuz Semiz, MD ^a,^⁎ , Ezgi Aktaş, MD ^b
^a Department of Dermatology, Health Science University Istanbul Haseki Training and Research Hospital, Istanbul, Turkey
^b Department of Dermatology, Health Science University Okmeydanı Training and Research Hospital (Prof Dr Cemil Taşcıoğlu City Hospital), Istanbul, Turkey

^∗Correspondence to: Yavuz Semiz, MD, Department of Dermatology, Istanbul Haseki Training and Research Hospital, Uğur Mumcu, Atatürk Blv No: 54, Sultangazi, Istanbul, 34265, Turkey.Department of DermatologyIstanbul Haseki Training and Research HospitalUğur MumcuAtatürk Blv No: 54SultangaziIstanbul34265Turkey

En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Thursday 05 December 2024

Abstract

Background

The etiopathogenesis of seborrheic dermatitis (SD) remains unexplained, although several factors have been considered in this regard.

Objective

The aim of this study is to investigate diet, metabolic status, and oxidative stress in SD patients.

Methods

This prospective, single-center, case-control study included 49 SD patients and 40 gender- and age-matched healthy controls.

Results

Dietary total antioxidant capacity values were significantly lower in SD patients than among the controls (7.16 ± 2.66 vs 12.85 ± 4.26; P < .001). Glycemic load (GL) values were significantly higher in SD patients (187.2 ± 57.2 vs 110.6 ± 46.5; P < .001). The glycemic index and GL values of patients with severe SD were significantly higher than those with mild SD (P = .014, P = .017; respectively).

Limitations

The cross-sectional design, small sample size, and the relatively short duration of questioning dietary habits are the limitations of the study.

Conclusion

A diet rich in antioxidants and with low glycemic index/GL content may be beneficial in the treatment of SD.

El texto completo de este artículo está disponible en PDF.

Key words : diet, glycemic load, metabolic syndrome, seborrheic dermatitis, total antioxidant capacity

Abbreviations used : BMI, BP, DTAC, GI, GL, HOMA-IR, MetS, OSI, SD, SDASI, TAC, TOC

Esquema

Introduction

Materials and methods

Clinical assessments

Dietary assessment

Assessment of dietary antioxidant capacity

Assessment of dietary gylycemic index and glycemic load values

	Funding sources: The study was funded by Turkish Society of Dermatology. There are no commercial funding sources in this study.
	Patient consent: Consent for the publication of recognizable patient photographs or other identifiable material was obtained by the authors and included at the time of article submission to the journal stating that all patients gave consent with the understanding that this information may be publicly available.
	IRB approval status: Reviewed and approved by the local ethics committee (protocol number: 280, date of approval: 14/12/2022).