Grip-Strength-Lean-Mass Index (GSLMI) as a valuable tool for sarcopenia diagnosis and survival prognosis in cancer patients: a nationwide multicenter cohort study - 12/11/24
, Hongxia Xu a, b, ⁎
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
Artículo gratuito.
Conéctese para beneficiarse!
Abstract |
Objectives |
To identify whether the Grip-Strength-Lean-Mass Index (GSLMI) can precisely diagnose sarcopenia and predict prognosis for cancer patients in clinical settings.
Design |
A nationwide multicenter cohort study.
Setting and participants |
8,831 inpatients aged 18 years and older, histologically diagnosed with cancer and receiving anti-cancer therapy.
Measurements |
The GSLMI is the ratio of hand grip strength (HGS) divided by lean mass (LM), calculated by the formula: GSLMI = HGS (kg) / LM (kg). Kaplan-Meier curves and Cox models were used to estimate the association between the GSLMI and survival.
Results |
A total of 3,071 (48.40%) male and 3,274 (51.60%) female patients were enrolled in the study. The prevalence of GLIS-defined sarcopenia was 2,646 (41.70%). The optimal sex-specific thresholds with the best diagnostic performance to identify a low GSLMI were determined to be <0.61 for males and <0.47 for females based on the ROC curves. According to Kaplan-Meier curves, patients with a high GSLMI exhibited better overall survival than those with a low GSLMI (HR = 0.664, 95%CI = 0.604−0.729, log-rank P < 0.001). Multivariable survival analysis revealed that the GSLMI showed an independent association with a lower hazard of death as a continuous variable (HR = 0.70, 95% CI = 0.51−0.96).
Conclusions |
The GSLMI may serve as a novel diagnostic tool for identifying sarcopenia and may have prognostic value for cancer patients. Using the GSLMI represents a feasible and promising option for better managing the health of patients with cancer.
El texto completo de este artículo está disponible en PDF.Keywords : Cancer, Sarcopenia, Hand grip strength, Lean mass, Mortality
Esquema
Vol 29 - N° 1
Artículo 100409- janvier 2025 Regresar al número
Artículo precedente
- Grip-Strength-Lean-Mass Index (GSLMI) as a valuable tool for sarcopenia diagnosis and survival prognosis in cancer patients: a nationwide multicenter cohort study
- Zhenyu Huo, Feifei Chong, Siyu Luo, Na Li, Ning Tong, Zongliang Lu, Jing Guo, Ling Zhang, Xin Lin, Mengyuan Zhang, Hongmei Zhang, Muli Shi, Xiumei He, Jie Liu, Chunhua Song, Hanping Shi, Hongxia Xu
- The association between peak expiratory flow rate and all-cause mortality among Chinese stroke survivors
- Yue-Ying Feng, Conghua Wang, Yuan-Mei Lan, Tian-Chao Chen, Hao-Qi Wu, Xin-Yi Liu, Xin-Juan Wu, Xiao-Ming Zhang
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.