Adjunctive Statin Therapy in Patients with Covid-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - 25/09/24
, Beatriz Araújo b, Vitor Leão Durães a, Ivo Queiroz c, Vanessa Henriques Carvalho, MD, PhD d, Tahir Haque, MD e, Taniela M. Bes, MD, PhD f
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Abstract |
Background |
The efficacy and safety of adjunctive statin therapy in hospitalized patients with coronavirus disease 2019 (Covid-19) remains uncertain.
Methods |
We systematically searched Medline, Embase, Cochrane, and ClinicalTrials.gov databases from inception to late April 2024 for randomized controlled trials (RCTs) comparing statin versus no statin use in patients hospitalized with Covid-19. We pooled risk ratios (RRs) and hazard ratios (HRs) with 95% confidence intervals (CIs) applying a random-effects model. R version 4.3.1 was used for statistical analyses.
Results |
We included 7 RCTs comprising 4,262 patients, of whom 2,645 (62%) were randomized to receive statin therapy. Compared with no statin, statin use significantly reduced case-fatality rate (RR 0.88; 95% CI 0.80-0.98; I2 = 0%). In a time-to-event analysis, we found similar results (HR 0.86; 95% CI 0.75-0.99; I2 = 0%). Statin use also significantly reduced World Health Organization (WHO) scale at 14 days (mean difference -0.27; 95% CI -0.54 to -0.01; I2 = 0%). There was no statistically significant difference between the two groups in length of hospital stay, elevation of liver enzymes, and C-reactive protein levels.
Conclusions |
In patients hospitalized with Covid-19, statins significantly reduced case-fatality rate and WHO scale score.
Registration |
A prospective register was recorded in International Prospective Register of Systematic Reviews (PROSPERO) with the number CRD42023479007.
El texto completo de este artículo está disponible en PDF.Keywords : Case-fatality rate, Coronavirus, Covid-19, Statins
Esquema
| Funding: There were no external funding sources for this study. |
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| Conflict of Interest: All authors declare no conflicts of interest and take full responsibility for the data's reliability and unbiased interpretation. |
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| Cynthia Florêncio de Mesquita, André Rivera, Beatriz Araújo, Vitor Leão Durães, and Ivo Queiroz Costa Neto are medical students. |
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| Authorship: CFM: Writing – original draft, Project administration, Methodology, Data curation, Conceptualization. AR: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. BA: Writing – original draft, Investigation, Formal analysis, Data curation. VD: Writing – original draft, Investigation, Data curation. IQ: Writing – review & editing, Methodology, Investigation, Formal analysis. VHC: Data curation. TH: Writing – review & editing. TMB: Writing – review & editing, Project administration. |
Vol 137 - N° 10
P. 966 - octobre 2024 Regresar al número
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