Application progress of nanomaterials in the treatment of prostate cancer - 24/09/24
Progrès de l’application des nanomatériaux dans le traitement du cancer de la prostate
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Highlights |
• | Unique advantages of nanomaterials: nanomaterials demonstrate significant potential in prostate cancer therapy due to their high targeting, drug release regulation, and therapeutic monitoring capabilities at the nanoscale. |
• | Sonodynamic therapy (SDT) and chemodynamic therapy (CDT): these emerging tumor treatment methods, enhanced by nanomaterials, utilize reactive oxygen species (ROS) to induce tumor cell death. |
• | Role of nanomaterials in SDT and CDT: acting as sonosensitizers or chemical sensitizers, nanomaterials improve the efficiency of SDT and CDT, amplifying the cytotoxic effects on tumor cells. |
• | Targeted drug delivery: nanomaterials facilitate targeted therapy in tumors through both passive and active targeting strategies, enhancing treatment efficacy and reducing side effects. |
• | Multimodal imaging and therapy monitoring: the application of nanomaterials in SDT allows for enhanced visibility and control, improving therapeutic outcomes through multimodal imaging techniques. |
• | Reversal of tumor drug resistance: nanomaterials contribute to overcoming chemoresistance in tumors through competitive and non-competitive inhibition, as well as gene silencing. |
• | Diagnosis and treatment of prostate cancer: nanostructured systems offer high research value in prostate cancer diagnostics and therapeutics, leveraging the enhanced permeability and retention (EPR) effect for prolonged tumor retention. |
• | Clinical translation potential: despite advancements in nanomaterial applications for prostate cancer treatment, challenges remain in design, synthesis, biocompatibility, and biosafety, necessitating further preclinical and clinical validation. |
• | Conclusion: the integration of nanomaterials in the treatment of prostate cancer presents significant potential and prospects, offering new avenues for early diagnosis, precise targeted therapy, and multimodal synergistic treatments. |
Summary |
Prostate cancer is one of the most common malignant tumors in men, which seriously threatens the survival and quality of life of patients. At present, there are serious limitations in the treatment of prostate cancer, such as drug tolerance, drug resistance and easy recurrence. Sonodynamic therapy and chemodynamic therapy are two emerging tumor treatment methods, which activate specific drugs or sonosensitizers through sound waves or chemicals to produce reactive oxygen species and kill tumor cells. Nanomaterials are a kind of nanoscale materials with many excellent physical properties such as high targeting, drug release regulation and therapeutic monitoring. Sonodynamic therapy and chemodynamic therapy combined with the application of nanomaterials can improve the therapeutic effect of prostate cancer, reduce side effects and enhance tumor immune response. This article reviews the application progress of nanomaterials in the treatment of prostate cancer, especially the mechanism, advantages and challenges of nanomaterials in sonodynamic therapy and chemodynamic therapy, which provides new ideas and prospects for research in this field.
El texto completo de este artículo está disponible en PDF.Résumé |
Le cancer de la prostate est l’un des plus courants des cancers chez l’homme, qui menace sérieusement la survie et la qualité de vie des patients. Actuellement, il y a des limitations graves dans le traitement du cancer de la prostate, tels que la tolérance au médicament, la résistance au médicament et la récidive facile. La thérapie sonodynamique et la thérapie chimiodynamique sont deux méthodes émergentes de traitement des tumeurs, qui activent des médicaments spécifiques ou des sonosensibilisants par des ondes sonores ou des produits chimiques pour produire des espèces réactives de l’oxygène et tuer les cellules tumorales. Les nanomatériaux sont des matériaux à nano-échelle avec de nombreuses excellentes propriétés physiques, telles que la haute ciblage, la régulation de la libération du médicament et la surveillance thérapeutique. La thérapie sonodynamique et la chimiodynamique combinées à l’application de nanomatériaux peuvent améliorer l’effet thérapeutique du cancer de la prostate, réduire les effets secondaires et renforcer la réponse immunitaire des tumeurs. Cet article passe en revue les progrès de l’application des nanomatériaux dans le traitement du cancer de la prostate, en particulier le mécanisme, les avantages et les défis des nanomatériaux dans la thérapie sonodynamique et chimiodynamique, ce qui offre de nouvelles idées et des perspectives pour la recherche dans ce domaine.
El texto completo de este artículo está disponible en PDF.Keywords : Prostate cancer, Nanomaterials, Sonodynamic therapy, Chemodynamic therapy, Targeted drug delivery
Mots clés : Cancer de la prostate, Nanomatériaux, Thérapie sonodynamique, Thérapie chimiodynamique, Livraison ciblée de médicaments
Esquema
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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