COVID-19 among lung cancer patients: Data from a real-life prospective French multicentric study - 07/06/24
On behalf of the Study Group KBP-2020-CPHG
Highlights |
• | The incidence of COVID-19 was higher in former smokers, specific histological subgroups, PS score ≥2 vs 0- and in stages III-IV vs I-II patients. |
• | In our cohort, the incidence COVID-19 was lower in active smokers, compared to former smokers and the chemotherapy had no impact. |
• | In 2020, COVID-19 had a major impact on mortality of LC patients with the risk of death being more than four times that of the population non-COVID-19. |
Summary |
Background |
COVID-19 started to spread early in 2020, the precise year that lung cancer (LC) patients were recruited into the prospective epidemiological cohort KBP-2020-CPHG in French hospitals. This provides a unique opportunity to study COVID-19 incidence, survival risk factors, and overall prognosis.
Methods |
COVID data was collected before vaccination was made available. Clinical characteristics were compared (COVID vs non-COVID), incidence rate ratios were calculated based on clinical characteristics, survival (1 and 3 months) was estimated and the impact of COVID-19 on the overall prognosis of the cohort was studied.
Results |
In 2020, 285 out of 8,999 lung cancer patients were diagnosed with COVID-19. Diagnosis was mainly based on PCR tests (86.3 %). The annual incidence was 8.3 % (95 % CI [7.4, 9.3]); it was higher in former smokers and patients with squamous cell carcinoma or small cell carcinoma than in those with adenocarcinoma, in those with a PS score ≥2 versus 0–1, and with stages III-IV versus stages I-II. The incidence was reduced in patients who received chemotherapy or immunotherapy. 64.9 % of patients were hospitalized due to COVID-19. Risk factors for death at 1 and 3 months in COVID-19 patients were age, LC stage, and PS score. Multivariate analysis showed a major prognostic impact of COVID-19 on mortality of LC patients (hazard ratio: 4.12, 95 % CI [3.42, 4.97], p < 0.001).
Conclusions |
This prospective study demonstrated the high incidence of COVID-19 in LC patients and identified as risk factors for COVID-19: smoking status, histology, PS, and stage. The impact of COVID-19 on lung cancer mortality appears major.
El texto completo de este artículo está disponible en PDF.Keywords : Lung cancer, Covid, Mortality, Stages
Esquema
Vol 86
Artículo 101093- novembre 2024 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.