Indigo naturalis (Qing dai) for inflammatory bowel disease: A systematic review and meta-analysis - 10/01/24
Highlights |
• | •What is already known on this subject?. |
• | There is an unmet need for new treatment options in the armamentarium of UC, with differing mechanisms of action and a better safety profile. Indigo naturalis is a traditional therapy reported to be useful in inflammatory bowel disease (IBD). |
• | •What are the new findings?. |
• | Indigo naturalis is effective in the treatment of ulcerative colitis and the systematic review suggests that almost 80 % of patients receiving the drug have a clinical response with a rare adverse event of pulmonary hypertension. |
• | •How might it impact on clinical practice in the foreseeable future?. |
• | Indigo naturalis is useful in the treatment of ulcerative colitis and provides clinicians with one more relatively cheap option. |
Abstract |
Background |
Indigo naturalis (Qing dai) is a traditional therapy reported to be useful in inflammatory bowel disease (IBD), especially for ulcerative colitis. We performed a systematic review of its efficacy and safety in IBD.
Methods |
Electronic databases (Pubmed, Embase, and Scopus) were searched on 4th March 2023 to identify reports about the use of indigo naturalis in IBD. We extracted data with respect to clinical response, remission, endoscopic and histological responses, and adverse events with the use of indigo naturalis in IBD. Pooled clinical response rates and remission rates were calculated. The quality of studies was assessed using Joanna-Briggs tools.
Results |
Nine studies reporting on 299 patients were included. The pooled clinical response rate was 0.796 (95 %CI, 0.7465–0.8379, I2=0), and the clinical remission rate in ulcerative colitis was 0.668 (0.488- 0.809, I2=85.2 %). The pooled relative risk of clinical response was higher in the indigo naturalis group as compared to placebo in the two randomized trials [3.82 (2.04; 7.14, I2=0)]. Except for one reversible pulmonary arterial hypertension case, most reported adverse effects were mild. The endoscopic and histological responses, when reported, suggested that indigo naturalis is effective for ulcerative colitis. The limitations of the systematic review included a small number of randomized studies, reports only from East Asia and a relatively small number of patients, especially for Crohn's disease.
Conclusion |
Indigo naturalis is effective in the treatment of ulcerative colitis. Future studies should evaluate the comparative efficacy with other drugs.
El texto completo de este artículo está disponible en PDF.Keywords : Indigo naturalis, Ulcerative colitis, Inflammatory bowel disease, Crohn's disease, Pulmonary artery hypertension, Complementary and alternative therapy
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Vol 48 - N° 1
Artículo 102250- janvier 2024 Regresar al número
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