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Health care resource use and costs among patients with carcinoid syndrome in France: Analysis of the National Health Insurance Database - 11/08/23

Doi : 10.1016/j.clinre.2023.102177 
Marine Perrier a, , Charbel Mouawad b, Delphine Gueguen b, Benoit Thomé c, Maryse Lapeyre-Mestre d, Thomas Walter a
a Department of Digestive Oncology, ENETS Centre of Excellence, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France 
b Ipsen Pharma, Boulogne Billancourt, France 
c Median conseil, Pau, France 
d Department of Medical and Clinical Pharmacology, Toulouse University Hospital, Toulouse, France 

Corresponding author at: Department of Digestive Oncology, ENETS Centre of Excellence, Edouard Herriot Hospital, Hospices Civils de Lyon, 5 Place d'Arsonval, 69003 Lyon, France.Department of Digestive Oncology, ENETS Centre of ExcellenceEdouard Herriot Hospital, Hospices Civils de Lyon5 Place d'ArsonvalLyon69003France

Highlights

The mean overall cost per person per month was €2892 in patients with carcinoid syndrome.
The first year following diagnosis and the year preceding death are the two periods representing the highest costs for carcinoid syndrome care in France.
The two most costly expenditure items were drugs and hospital stays.
Estimating direct and indirect costs of carcinoid syndrome are important drivers of public health decision making.

El texto completo de este artículo está disponible en PDF.

Abstract

Objectives

Carcinoid syndrome (CS) develops in approximately 20% of patients with neuroendocrine tumours (NET). This study described healthcare resource utilization and its associated costs among patients with NET and CS, using the French national health care data system.

Methods

Patients were included if they had a hospital stay associated with the code E34.0 "CS" and at least one delivery of a somatostatin analogue (SSA) between 01/01/2012 and 31/12/2016. The end of the analysis was either 31/12/2017 or the date of death, whichever occurred first. Mean overall costs were described by item of expenditure and by periods.

Results

646 patients were included: 64yo, 55% men, 64% and 15% had NET from the small-intestine or lung, respectively. Among them, 309 patients were incident and 271 died during the study period. Mean overall cost per person per month (PPPM) was €2,892: €3,273 for the first year following diagnosis, €2,574 in “middle-years” and €5,039 within the year preceding death. The two most costly expenditure items were drugs (€1,695 PPPM) and hospital stays (€870 PPPM).

Conclusion

The first year following diagnosis and the year preceding death are the two periods representing the highest costs for CS care in France. Successful disease management may contribute to lower costs in the intermediate period.

El texto completo de este artículo está disponible en PDF.

Keywords : Carcinoid syndrome, Resources, Healthcare expenditure, Cost, Neuroendocrine tumours


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Vol 47 - N° 7

Artículo 102177- août 2023 Regresar al número
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