Clinicopathological characteristics of autoimmune gastritis: A single-center retrospective study - 11/08/23
, Wei-Feng Huang a, c, ⁎ Highlights |
• | What is already known on this subject?. |
• | Autoimmune gastritis is a prominent risk factor for pernicious anemia and gastric neoplasia. |
• | What are the new findings?. |
• | This study highlights the increased risk of severe anemia in AIFA-positive patients, particularly for pernicious anemia. |
• | How might it impact on clinical practice in the foreseeable future?. |
• | Clinicians should consider the presence of AIFA as a warning sign for severe anemia. |
Abstract |
Background and Aim |
Autoimmune gastritis (AIG) is a prominent risk factor for pernicious anemia (PA) and gastric neoplasia. This study aimed to investigate the clinicopathological characteristics of AIG patients in China, with a focus on those who had positive anti-intrinsic factor antibodies (AIFA).
Methods |
A total of 103 AIG patients who were diagnosed between January 2018 and August 2022 were reviewed in a large academic tertiary teaching hospital. Patients were divided into two groups based on the presence or absence of AIFA, and their serologic and histopathological characteristics were analyzed.
Results |
The mean age of the 103 AIG patients was 54.16±11.92 years (range 23–79), with 69 (66.99%) being women. AIFA were present in 28.16% of patients. Patients with AIFA-positive had a higher risk of PA than those with AIFA-negative, as demonstrated by a larger mean corpuscular volume (MCV), lower hemoglobin level, and lower vitamin B-12 level (P<0.05). There were no statistically significant differences in gastric histopathology, gastrin level, and pepsinogen level when patients were divided into AIFA-positive and AIFA-negative group. Of the 103 cases, 34 (33.01%) were concomitant with other autoimmune diseases, with autoimmune thyroid diseases being the most common (25.24%, 26/103). Thyroid peroxidase antibody, which accounted for 45.45% (25/55), was the most prevalent thyroid antibody, followed by anti-thyroglobulin antibody (34.55%, 19/55), thyroid stimulating antibody (12.73%, 7/55), and thyrotropin receptor antibody (3.64%, 2/55).
Conclusion |
This study highlights the increased risk of severe anemia in AIFA-positive AIG patients, particularly for PA. Clinicians should consider the presence of AIFA as a warning sign for PA and prioritize early diagnosis and appropriate treatment to prevent serious complications.
El texto completo de este artículo está disponible en PDF.Keywords : Autoimmune gastritis, Clinicopathological characteristics, Anti-intrinsic factor antibodies, Anti-parietal cells antibodies
Esquema
Vol 47 - N° 7
Artículo 102154- août 2023 Regresar al número
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