T lymphocyte-mediated pyroptosis: A new regulatory mechanism in non-viral liver disease - 02/02/23
, Junfeng Li a, c, ⁎ Abstract |
T lymphocyte-mediated pyroptosis plays an important role in the development of non-viral liver diseases. Pyroptosis as a programmed cell death process, has been a hot topic of research on disease pathogenesis in recent years. As one of the most common immune cells in the body, T cells are the major players in adaptive immunity. An increasing number of studies have shown that T lymphocyte-mediated pyroptosis functions in non-viral liver diseases to regulate immune function, alter the immune microenvironment, and thus influence disease progression. These findings will guide us and provide new ideas for the development of subsequent therapeutic agents for non-viral liver diseases.
El texto completo de este artículo está disponible en PDF.Keywords : T-lymphocyte, Pyroptosis, Non-viral liver disease, Nonalcoholic fatty liver disease, Alcoholic liver disease, Autoimmune liver disease
Abbreviations : LPS, GSDM, IL-1β, IL-18, NLRP1, NLRP3, NLRC4, AIM2, NAIPS, ASC, PRR, ALR, Th cell, Treg cell, Tfh cell, Tr1 cell, nTreg cell, iTreg cell, NKT cell, iNKT cell, PDAC, IFN-I, NAFLD, ALD, CCR2, CCR5, CCL2, IOE, MOF, TME, DC, NAPSB, IFNAR
Esquema
| Author Contributions: Wanyuan Xiong, Junfeng Li designed the paper. Wanyuan Xiong, Zibing Qian wrote the manuscript. Xiaorong Mao, Junfeng Li revised and polished the paper. |
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| Funding information: The Natural Science Foundation of Gansu Province (20JR5RA364); The Fund of the First Hospital of Lanzhou University (ldyyyn2020–02) The Fund of the First Hospital of Lanzhou University (ldyyyn2020–14); Gansu Clinical Medical Research Center of Infection & Liver Diseases(21JR7RA392); The Natural Science Foundation of Gansu Province (21JR1RA070). |
Vol 47 - N° 2
Artículo 102070- février 2023 Regresar al número
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