Ribavirin-resistant chronic norovirus infection-associated enteropathy in common variable immunodeficiency. Case report and review of the literature - 01/10/22
, Beatriz Calderón-Hernanz a, Joaquín Serrano-López de las Hazas a, Ana Isabel de Hita-Santabaya b, Joan Riera-Oliver cAbstract |
Chronic Norovirus infection is particularly challenging in patients with common variable immunodeficiency (CVID) because of their inability to achieve viral clearance and the risk of developing enteropathy leading to intestinal villous atrophy and malabsorption. To date, therapeutic options to eliminate the virus are limited and only ribavirin has been shown to induce viral clearance in norovirus enteropathy associated with CVID. We report a case of a 48-year-old female patient diagnosed with CVID enteropathy possibly related to norovirus infection who failed a ribavirin-based therapy despite dosage optimization through drug plasma level monitoring.
El texto completo de este artículo está disponible en PDF.Keywords : Norovirus, Common variable immunodeficiency, Intestinal diseases, Ribavirin, Therapeutic drug monitoring
Abbreviations : CVID, RBV
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Vol 46 - N° 8
Artículo 101956- octobre 2022 Regresar al número
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