Research progress on classical traditional Chinese medicine Taohong Siwu decoction in the treatment of coronary heart disease - 18/06/22
Abstract |
The pathogenesis of coronary heart disease is closely related to blood stasis. Taohong Siwu decoction (THSW for short) is one of the most widely used prescriptions for activating blood and removing stasis. Clinical research has confirmed its curative effect on coronary heart disease. However, its underlying mechanism remains unclear. Therefore, this paper reviewed the clinical efficacy of THSW and determine its effective components based on a comprehensive literature review. Furthermore, the core components and targets of THSW in treating coronary heart disease using molecular docking were verified, and the interaction sites were predicted to construct a theoretical basis for the clinical application of THSW.
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Highlights |
• | Taohong Siwu Decoction is a classic recipe for promoting blood circulation and removing blood stasis. |
• | Taohong Siwu Decoction is widely used in the treatment of coronary heart disease. |
• | The key components of Taohong Siwu Decoction are Quercetin, Kaempferol, Sitogluside, Apigenin, Stigmasterol. And the key components of Taohong Siwu Decoction can nourish blood and promote blood circulation by regulating AKT1, IL6, INS, TNF, TP53, JUN, Casp3, and VEGFA. |
Keywords : Taohong Siwu decoction, Coronary heart disease, Pharmacological mechanism, Clinical role
Esquema
Vol 152
Artículo 113249- août 2022 Regresar al número
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