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Guidelines for the management of patients with severe acute pancreatitis, 2021 - 15/06/22

Doi : 10.1016/j.accpm.2022.101060 
Samir Jaber a, b, , Marc Garnier c, Karim Asehnoune d, e, Fanny Bounes f, g, Louis Buscail h, Jean-Baptiste Chevaux i, Claire Dahyot-Fizelier j, k, Lucie Darrivere l, Matthieu Jabaudon m, n, Olivier Joannes-Boyau o, Yoann Launey p, Eric Levesque q, r, Philippe Levy s, Philippe Montravers t, u, Laurent Muller v, Thomas Rimmelé w, x, Claire Roger v, y, Céline Savoye-Collet z, Philippe Seguin A, Jean-Pierre Tasu B, C, Ronan Thibault D, Geoffroy Vanbiervliet E, Emmanuel Weiss F, G, H, Audrey De Jong a, b
a Department of Anaesthesiology and Intensive Care (DAR B), University Hospital Center Saint Eloi Hospital, Montpellier, France 
b PhyMedExp, Montpellier University, INSERM, CNRS, CHU de Montpellier, Montpellier, France 
c Sorbonne Université, GRC 29, DMU DREAM, Service d’Anesthésie-Réanimation et Médecine Périopératoire Rive Droite, Paris, France 
d Service d'Anesthésie, Réanimation chirurgicale, Hôtel Dieu/HME, CHU Nantes, Nantes cedex 1, France 
e Inserm, UMR 1064 CR2TI, team 6, France 
f Toulouse University Hospital, Anaesthesia Critical Care and Perioperative Medicine Department, Toulouse, France 
g Équipe INSERM Pr Payrastre, I2MC, Université Paul Sabatier Toulouse III, Toulouse, France 
h Department of Gastroenterology & Pancreatology, University of Toulouse, Rangueil Hospital, Toulouse, France 
i Service HépatoGastroEntérologie, Brabois Adultes, CHRU Nancy, France 
j Anaesthesiology and Intensive Care Department, University hospital of Poitiers, Poitiers, France 
k INSERM U1070, University of Poitiers, Poitiers, France 
l Department of Anaesthesia and Critical Care Medicine, AP-HP, Hôpital Lariboisière, F-75010, Paris, France 
m Department of Perioperative Medicine, CHU Clermont-Ferrand, Clermont-Ferrand, France 
n iGReD, Université Clermont Auvergne, CNRS, INSERM, Clermont-Ferrand, France 
o Service d’Anesthésie-Réanimation SUD, CHU de Bordeaux, Hôpital Magellan, Bordeaux, France 
p Critical Care Unit, Department of Anaesthesia, Critical Care and Perioperative Medicine, University Hospital of Rennes, Rennes, France 
q Department of Anaesthesia and Surgical Intensive Care, AP-HP, Henri Mondor Hospital, Créteil, France 
r Université Paris-Est Creteil, EnvA, DYNAMiC, Faculté de Santé de Créteil, Creteil, France 
s Service de Pancréatologie et d’Oncologie Digestive, DMU DIGEST, Université de Paris, Hôpital Beaujon, APHP, Clichy, France 
t Université de Paris Cité, INSERM UMR 1152 – PHERE, Paris, France 
u Département d’Anesthésie-Réanimation, APHP, CHU Bichat-Claude Bernard, DMU PARABOL, APHP, Paris, France 
v Réanimations et surveillance continue, Pôle Anesthésie Réanimation Douleur Urgences, CHU Nîmes Caremeau, Montpellier, France 
w Département d’anesthésie-réanimation, Hôpital Édouard Herriot, Hospices Civils de Lyon, Lyon, France 
x EA 7426: Pathophysiology of Injury-induced Immunosuppression, Pi3, Hospices Civils de Lyon-Biomérieux-Université Claude Bernard Lyon 1, Lyon, France 
y Department of Intensive care medicine, Division of Anaesthesiology, Intensive Care, Pain and Emergency Medicine, Nîmes University Hospital, Nîmes, France 
z Department of Radiology, Normandie University, UNIROUEN, Quantif-LITIS EA 4108, Rouen University Hospital-Charles Nicolle, Rouen, France 
A Service d’Anesthésie Réanimation 1, Réanimation chirurgicale, CHU de Rennes, Rennes, France 
B Service de radiologie diagnostique et interventionnelle, CHU de Poitiers, Poitiers, France 
C LaTim, UBO and INSERM 1101, University of Brest, Brest, France 
D Service Endocrinologie-Diabétologie-Nutrition, CHU Rennes, INRAE, INSERM, Univ Rennes, NuMeCan, Nutrition Metabolisms Cancer, Rennes, France 
E Department of Digestive Endoscopy, Centre Hospitalier Universitaire de Nice, Nice, France 
F Department of Anaesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP.Nord, Clichy, France 
G University of Paris, Paris, France 
H Inserm UMR_S1149, Centre for Research on Inflammation, Paris, France 

Corresponding author at: Department of Anaesthesiology and Intensive Care (DAR B), University Hospital Center Saint Eloi Hospital, Montpellier, France.Department of Anaesthesiology and Intensive Care (DAR B)University Hospital Center Saint Eloi HospitalMontpellierFrance

Abstract

Objective

To provide guidelines for the management of the intensive care patient with severe acute pancreatitis.

Design

A consensus committee of 22 experts was convened. A formal conflict-of-interest (COI) policy was developed at the beginning of the process and enforced throughout. The entire guideline construction process was conducted independently of any industrial funding (i.e. pharmaceutical, medical devices). The authors were required to follow the rules of the Grading of Recommendations Assessment, Development and Evaluation (GRADE®) system to guide assessment of quality of evidence. The potential drawbacks of making strong recommendations in the presence of low-quality evidence were emphasised.

Methods

The most recent SFAR and SNFGE guidelines on the management of the patient with severe pancreatitis were published in 2001. The literature now is sufficient for an update. The committee studied 14 questions within 3 fields. Each question was formulated in a PICO (Patients Intervention Comparison Outcome) format and the relevant evidence profiles were produced. The literature review and recommendations were made according to the GRADE® methodology.

Results

The experts' synthesis work and their application of the GRADE® method resulted in 24 recommendations. Among the formalised recommendations, 8 have high levels of evidence (GRADE 1+/−) and 12 have moderate levels of evidence (GRADE 2+/−). For 4 recommendations, the GRADE method could not be applied, resulting in expert opinions. Four questions did not find any response in the literature. After one round of scoring, strong agreement was reached for all the recommendations.

Conclusions

There was strong agreement among experts for 24 recommendations to improve practices for the management of intensive care patients with severe acute pancreatitis.

El texto completo de este artículo está disponible en PDF.

Keywords : Guidelines, Severe acute pancreatitis, Acute respiratory distress syndrome, Sepsis, Intensive care unit, Critical care


Esquema


 Validated by the SFAR Clinical Guidelines Committee on the 24th of June 2021 and by the SFAR Board of Directors on the 30th of June 2021.
⋆⋆ Guidelines issued by the French Society of Anaesthesia and Intensive Care Medicine (Société française d’anesthésie et de réanimation - SFAR), in collaboration with: the French National Society of Gastroenterology (Société nationale française de gastro-entérologie - SNFGE), the French Association of Surgery (Association française de chirurgie - AFC), the French Society of Radiology (Société française de radiologie - SFR), the French Speaking Society of Clinical Nutrition and Metabolism (Société francophone de nutrition clinique et métabolisme - SFNCM), and the French Society of Digestive Endoscopy (Société française d’endoscopie digestive - SFED).


© 2022  Publicado por Elsevier Masson SAS.
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