Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review - 20/04/22

Doi : 10.1016/j.biopha.2022.112843

Talal Almas ^a,^⁎ , Sarah Rehman ^b, Eyad Mansour ^a, Tarek Khedro ^a, Ali Alansari ^c, Jahanzeb Malik ^d, Norah Alshareef ^a, Vikneswaran Raj Nagarajan ^a, Abdulla Hussain Al-Awaid ^a, Reema Alsufyani ^a, Majid Alsufyani ^a, Ali Rifai ^a, Ahlam Alzahrani ^a, Dhineswaran Raj Nagarajan ^e, Tala Abdullatif ^f, Varman Gunasaegaram ^g, Enaam Alzadjali ^a, Arthi Subramanian ^a, Abida Rahman ^h, Yasar Sattar ⁱ, Jason Galo ^j, Hafeez Ul Hassan Virk ^k, M. Chadi Alraies ^l
^a Royal College of Surgeons in Ireland, Dublin, Ireland
^b Aga Khan University, Karachi, Pakistan
^c University Hospital, National University of Ireland Galway, Galway, Ireland
^d Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan
^e Sunway University School of Medicine and Health Science, Malaysia
^f National University of Ireland, Galway, Ireland
^g Galway University Hospital, Galway, Ireland
^h Trinity Centre for Global Health, Trinity College Dublin, Ireland
ⁱ Department of Cardiology, West Virginia University, Morgantown, WV, USA
^j Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA
^k Adena Regional Medical Center, Chillicothe, OH, USA
^l Department of Interventional Cardiology, Detroit Medical Center, DMC Heart Hospital, Detroit, MI, USA

^⁎Correspondence to: Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin, Ireland.Royal College of Surgeons in Ireland123 St. Stephen’s GreenDublinIreland

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Abstract

The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology.

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Keywords : Coronavirus 2019 (COVID-19), SARS-CoV-2, COVID-19 mRNA vaccine, COVID-19 myocarditis, COVID-19 perimyocarditis, Takotsubo syndrome

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Myocardial infarction

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Vol 149

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Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review - 20/04/22

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