Association Between Cinnamon Consumption and Risk of Cardiovascular Health: A Systematic Review and Meta-Analysis - 15/12/21
, Ameesh Isath, MD c, Claire Ziemba Scott, MD a, b, Zhen Wang, MD d, e, Scott Kaplin, MD f, Hani Jneid, MD a, b, Carl J. Lavie, MD g, Salim S. Virani, MD, PhD a, bAbstract |
Background |
Cinnamon has been used as a traditional herbal medication for decades. Several studies have investigated cinnamon consumption and cardiovascular risk. So far, the evidence remains inconclusive. Thus, we aim to systematically review the currently available literature and quantify the evidence, if possible.
Methods |
We systematically searched Ovid MEDLINE, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Scopus, and Web of Science from database inception in 1966 through December 2020. The exposure of interest was cinnamon consumption, the outcome was cardiovascular risk defined as hemoglobin A1C, low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c). Two investigators independently reviewed the data. Conflicts were resolved through consensus. Random-effects meta-analyses were used.
Results |
Of 23 studies (1070 subjects), the included studies were heterogeneous, generally of very poor quality. We found no difference in LDL-c levels in patients who consumed cinnamon vs those who did not, with a weighted mean difference (WMD) of 0.38 (confidence interval [CI], −6.07-6.83). We also found no difference in HDL-c between the 2 groups with WMD 0.40 (CI, −1.14-1.94). In addition, we found no statistical differences in hemoglobin A1C between the 2 groups with WMD of 0.0 (CI, −0.44-0.45).
Conclusions |
Our meta-analysis suggests that there is no association between cinnamon consumption and differences in LDL-c, HDL-c, and hemoglobin A1C levels. Further randomized control trials studies using a robust design with long-term cinnamon consumption are needed to further investigate any potential effect.
El texto completo de este artículo está disponible en PDF.Keywords : Cardiovascular health, Cinnamon consumption, Meta-analysis, Systematic review
| Funding: None. |
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| Conflicts of Interest: CK discloses the following relationships: Member of the American College of Cardiology Solution Set Oversight Committee, the American Heart Association Committee of the Council on Genomic and Precision Medicine, and the American College of Cardiology/American Heart Association Task Force on Performance Measures, The Lancet Digital Health (Advisory Board), European Heart Journal Digital Health (Editorial board), Journal of the American Heart Association (Editorial Board), Journal of the American College of Cardiology: Asia (Section Editor), and The Journal of Scientific Innovation in Medicine (Associate Editor). SSV discloses the following relationships: Grant support: Department of Veterans Affairs, World Heart Federation, Tahir and Jooma Family Honorarium: American College of Cardiology (Associate Editor for Innovations, ACC.org) Steering Committee: Patient and Provider Assessment of Lipid Management (PALM) registry at Duke Clinical Research Institute (no financial remuneration). All other authors have no disclosures. |
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| Authorship: All authors had access to the data and a role in writing the manuscript. CK: conceptualization, methodology, data extraction, software, analysis writing – original draft preparation; AI: data extraction, data curation software; investigation; CZS: writing – reviewing and editing; ZW: methodology, data extraction, software, analysis; SK: writing – reviewing and editing, validation; HJ: writing – reviewing and editing; CJL: writing – reviewing and editing; SSV: writing – reviewing and editing. |
Vol 135 - N° 1
P. 110-117 - janvier 2022 Regresar al número
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