Capillary leak syndrome: State of the art in 2021 - 13/11/21
Syndrome de fuite capillaire : état de l’art en 2021
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Abstract |
Capillary leak syndrome (CLS) is an increasingly acknowledged multifaceted and potentially lethal disease. Initial nonspecific symptoms are followed by the intriguing CLS hallmark: the double paradox associating diffuse severe edema and hypovolemia, along with hemoconcentration and hypoalbuminemia. Spontaneous resolutive phase is often associated with poor outcome due to iatrogenic fluid overload during leak phase. CLS is mainly triggered by drugs (anti-tumoral therapies), malignancy, infections (mostly viruses) and inflammatory diseases. Its idiopathic form is named after its eponymous finder: Clarkson's disease. CLS pathophysiology involves a severe, transient and multifactorial endothelial disruption which mechanisms are still unclear. Empirical and based-on-experience treatment implies symptomatic care during the acute phase (with the eventual addition of drugs amplifying cAMP levels in the severest cases), and the prophylactic use of monthly polyvalent immunoglobulins to prevent relapses. As CLS literature is scattered, we aimed to collect and summarize the current knowledge on CLS to facilitate its diagnosis, understanding and management.
El texto completo de este artículo está disponible en PDF.Keywords : Capillary leak syndrome, Vascular leak syndrome, Clarkson's disease, Clarkson's syndrome
Esquema
Vol 42 - N° 11
P. 789-796 - novembre 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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