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Association between time to advanced airway management and neurologically favourable survival during out-of-hospital cardiac arrest - 01/09/21

Doi : 10.1016/j.accpm.2021.100906 
Tatsuma Fukuda a, , 1 , Naoko Ohashi-Fukuda b, 1, Ryota Inokuchi c, Yutaka Kondo d, e, Hiroshi Sekiguchi a, Takayuki Taira a, f, Ichiro Kukita a, g
a Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan 
b Department of Emergency and Critical Care Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 
c Department of Health Services Research, University of Tsukuba, Ibaraki, Japan 
d Department of Emergency and Critical Care Medicine, Juntendo University Urayasu Hospital, Chiba, Japan 
e Department of Clinical Epidemiology and Health Economics, The University of Tokyo, Tokyo, Japan 
f Department of Anaesthesiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan 
g Department of Medical Engineering, University of the Ryukyus Hospital, Okinawa, Japan 

Corresponding author at: Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa, 903-0215, Japan.Department of Emergency and Critical Care MedicineGraduate School of MedicineUniversity of the Ryukyus207 UeharaNishihara-choOkinawa903-0215Japan

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Abstract

Background

Advanced airway management (AAM) is commonly performed as part of advanced life support. However, there is controversy about the association between the timing of AAM and outcomes after out-of-hospital cardiac arrest (OHCA). This study aimed to determine whether time to AAM is associated with outcomes after OHCA.

Methods

This was a nationwide population-based observational study using the Japanese government-led registry of OHCA. Adults who experienced OHCA and received AAM by EMS personnel in the prehospital setting from 2014 to 2017 were included. Multivariable logistic regression models were used to assess the associations between time to AAM (defined as time in minutes from emergency call to the first successful AAM) and outcomes after OHCA. Then, associations between early (≤ 20 min) vs. delayed (> 20 min) AAM and outcomes after OHCA were examined using propensity score-matched analyses. The primary outcome was one-month neurologically favourable survival.

Results

A total of 164,223 patients (median [IQR] age, 80 [69−86] years; 57.7% male) were included. The median time to AAM was 17 min (IQR, 14−22). Longer time to AAM was significantly associated with a decreased chance of one-month neurologically favourable survival (multivariable adjusted OR per minute delay, 0.90 [95% CI, 0.90−0.91]). In the propensity score-matched cohort, compared with early AAM, delayed AAM was associated with a decreased chance of one-month neurologically favourable survival (516 of 50,997 [1.0%] vs. 226 of 50,997 [0.4%]; RR, 0.44; 95% CI, 0.37−0.51; NNT, 176).

Conclusions

Delay in AAM was associated with a decreased chance of one-month neurologically favourable survival among patients with OHCA.

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Keywords : Out-of-hospital cardiac arrest, Cardiopulmonary resuscitation, Advanced airway management, Endotracheal intubation, Supraglottic airway device


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© 2021  Société française d'anesthésie et de réanimation (Sfar). Publicado por Elsevier Masson SAS. Todos los derechos reservados.
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Vol 40 - N° 4

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