Suscribirse

French multicentre observational study on SARS-CoV-2 infections intensive care initial management: the FRENCH CORONA study - 01/09/21

Doi : 10.1016/j.accpm.2021.100931 
Claire Roger a, b, , Olivier Collange c, Myriam Mezzarobba d, Osama Abou-Arab e, Lauranne Teule f, Marc Garnier g, Clément Hoffmann h, Laurent Muller a, b, Jean-Yves Lefrant a, b, Pierre Grégoire Guinot i, Emmanuel Novy j, Paul Abraham k, Thomas Clavier l, Jérémy Bourenne m, Guillaume Besch n, Laurent Favier o, Michel Fiani p, Alexandre Ouattara q, Olivier Joannes-Boyau q, Marc-Olivier Fischer r, Marc Leone s, Younes Ait Tamlihat t, Julien Pottecher u, Pierre-Yves Cordier v, Philippe Aussant w, Mouhamed Djahoum Moussa x, Etienne Hautin y, Marine Bouex z, Jean-Michel Julia aa, Julien Cady bb, Marc Danguy Des Déserts cc, Nicolas Mayeur dd, Thibault Mura d, Bernard Allaouchiche ee

for the AZUREA group

a Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Nîmes, France 
b UR UM103 IMAGINE, Faculté de Médecine, Univ Montpellier, Montpellier, France 
c Service d’Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France 
d Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, CHU Nîmes, University Montpellier, Nîmes, France 
e Department of Anaesthesiology and Critical Care Medicine, Amiens Picardie University Hospital, 1 rue du Professeur Christian Cabrol, 80054 Amiens, France 
f Medical and Surgical Intensive Care Unit, Centre Hospitalier de Perpignan, Perpignan, France 
g Sorbonne University, GRC29, AP-HP, DMU DREAM, Department of Anaesthesiology and Critical Care Medicine, St Antoine Hospital, Paris, France 
h Percy Military Teaching Hospital, Burn Centre, France 
i Anaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, 2 Bd Maréchal de Lattre de Tassigny, 21000, Dijon, France 
j Department of Anaesthesiology and Critical Care Medicine, Institut Lorrain du Coeur et des Vaisseaux, University Hospital of Nancy-Brabois, Vandoeuvre-Lès-Nancy, France 
k Department of Anaesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France 
l Department of Anaesthesiology and Critical Care, Rouen University Hospital, Rouen, France; Normandie Univ, UNIROUEN, Inserm U1096, 76000 Rouen, France 
m Department of Emergency and Intensive Care Medicine, University Hospital of Marseille, Hôpital de la Timone, Aix Marseille University, Marseille, France 
n Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Besançon, Besançon, France; University of Franche-Comte, EA3920, Besançon, France 
o Service de Réanimation Polyvalente, Centre Hospitalier de Béziers, France 
p Service de Réanimation, CH Château Thierry, France 
q Service d'Anesthésie-Réanimation Sud, Centre Médico-Chirurgical Magellan, Centre Hospitalier Universitaire (CHU) de Bordeaux, 33000 Bordeaux, France 
r Department of Anaesthesiology and Critical Care, Normandie Université, UNICAEN, CHU de Caen Normandie, 14000 Caen, France 
s Department of Anaesthesiology and Intensive Care Medicine, Hôpital Nord, Assistance Publique Hôpitaux de Marseille, Aix Marseille University, 13015, Marseille, France 
t Service de Réanimation, CH Saintonge, France 
u Service d’Anesthésie-Réanimation & Médecine Péri-opératoire, Hôpitaux Universitaires de Strasbourg (HUS), Strasbourg, France; UR 3072, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France 
v Hôpital d'Instruction des Armées Laveran, Marseille, France 
w Service de Réanimation, CH Lisieux, France 
x CHU Lille, Pôle d'Anesthésie-Réanimation, F-59000, Lille, France 
y Department of Anaesthesiology and Intensive Care, Ramsay Sante, Clinique de la Sauvegarde, Lyon, France 
z Service de Réanimation, CH Alès, France 
aa Anesthésie et Réanimation, Clinique du Parc, Castelnau-Le-Lez, France 
bb Institut Arnault Tzanck, Saint Laurent du Var, France 
cc Service de Réanimation Polyvalente, Pôle Bloc Anesthésie Réanimation Urgences, Hôpital d'Instruction des Armées Clermont Tonnerre, Brest, France 
dd Department of Anaesthesiology and Intensive Care Unit, Clinique Pasteur, 45 avenue de Lombez BP27617, 31076 Toulouse Cedex 03, France 
ee Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Service de Réanimation, 69310, Pierre-Bénite, France 

Corresponding author at: Department of Anaesthesiology and Intensive Care, Pain and Emergency medicine, Nîmes-Caremeau University Hospital, Place du Professeur Robert Debré, 30029 Nîmes cedex 9, France.Department of Anaesthesiology and Intensive Care, Pain and Emergency medicineNîmes-Caremeau University HospitalPlace du Professeur Robert DebréNîmes cedex 930029France

Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
Artículo gratuito.

Conéctese para beneficiarse!

Abstract

Aim

Describing acute respiratory distress syndrome patterns, therapeutics management, and outcomes of ICU COVID-19 patients and indentifying risk factors of 28-day mortality.

Methods

Prospective multicentre, cohort study conducted in 29 French ICUs. Baseline characteristics, comorbidities, adjunctive therapies, ventilatory support at ICU admission and survival data were collected.

Results

From March to July 2020, 966 patients were enrolled with a median age of 66 (interquartile range 58–73) years and a median SAPS II of 37 (29–48). During the first 24 h of ICU admission, COVID-19 patients received one of the following respiratory supports: mechanical ventilation for 559 (58%), standard oxygen therapy for 228 (24%) and high-flow nasal cannula (HFNC) for 179 (19%) patients. Overall, 721 (75%) patients were mechanically ventilated during their ICU stay. Prone positioning and neuromuscular blocking agents were used in 494 (51%) and 460 (48%) patients, respectively. Bacterial co-infections and ventilator-associated pneumonia were diagnosed in 79 (3%) and 411 (43%) patients, respectively. The overall 28-day mortality was 18%. Age, pre-existing comorbidities, severity of respiratory failure and the absence of antiviral therapy on admission were identified as independent predictors of 28-day outcome.

Conclusion

Severity of hypoxaemia on admission, older age (> 70 years), cardiovascular and renal comorbidities were associated with worse outcome in COVID-19 patients. Antiviral treatment on admission was identified as a protective factor for 28-day mortality. Ascertaining the outcomes of critically ill COVID-19 patients is crucial to optimise hospital and ICU resources and provide the appropriate intensity level of care.

El texto completo de este artículo está disponible en PDF.

Abbreviations : ICU, LOS, ARDS, SAPS II, SOFA, RRT, ECMO, IMV, NIV, HFNC

Keywords : Viral pneumonia, Outcome, COVID-19, Management


Esquema


© 2021  Société française d'anesthésie et de réanimation (Sfar). Publicado por Elsevier Masson SAS. Todos los derechos reservados.
Añadir a mi biblioteca Eliminar de mi biblioteca Imprimir
Exportación

    Exportación citas

  • Fichero

  • Contenido

Vol 40 - N° 4

Artículo 100931- août 2021 Regresar al número
Artículo precedente Artículo precedente
  • What is the most adequate non-invasive oxygen support for acute hypoxaemic respiratory failure due to COVID-19?
  • Jean-Pierre Frat, Arnaud W. Thille, François Arrivé, Manel Lujan, Jordi Rello
| Artículo siguiente Artículo siguiente
  • Deployment of a mobile military ICU embedded in a civilian hospital during the second COVID-19 outbreak in Mayotte, France
  • Quentin Mathais, Astrée Swiech, Gaël De Rocquigny, Chloé Thill, Philippe Aries

Bienvenido a EM-consulte, la referencia de los profesionales de la salud.

Mi cuenta


Declaración CNIL

EM-CONSULTE.COM se declara a la CNIL, la declaración N º 1286925.

En virtud de la Ley N º 78-17 del 6 de enero de 1978, relativa a las computadoras, archivos y libertades, usted tiene el derecho de oposición (art.26 de la ley), el acceso (art.34 a 38 Ley), y correcta (artículo 36 de la ley) los datos que le conciernen. Por lo tanto, usted puede pedir que se corrija, complementado, clarificado, actualizado o suprimido información sobre usted que son inexactos, incompletos, engañosos, obsoletos o cuya recogida o de conservación o uso está prohibido.
La información personal sobre los visitantes de nuestro sitio, incluyendo su identidad, son confidenciales.
El jefe del sitio en el honor se compromete a respetar la confidencialidad de los requisitos legales aplicables en Francia y no de revelar dicha información a terceros.


Todo el contenido en este sitio: Copyright © 2024 Elsevier, sus licenciantes y colaboradores. Se reservan todos los derechos, incluidos los de minería de texto y datos, entrenamiento de IA y tecnologías similares. Para todo el contenido de acceso abierto, se aplican los términos de licencia de Creative Commons.