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Is “pain before vomiting” useful?: Diagnostic performance of the classic patient history item in acute appendicitis - 24/02/21

Doi : 10.1016/j.ajem.2020.12.066 
Toshihiko Takada, PhD a, b, , Ryota Inokuchi, PhD c, d, Hongja Kim, MD e, Sho Sasaki, DrPh b, f, Kazuhiko Terada, MD g, Hajime Yokota, PhD h, Shinya Hattori, PhD i, Wakako Mikami, PhD j, Tadao Kubota, MD k, Shunichi Fukuhara, DMSc a, l
a Department of General Medicine, Shirakawa Satellite for Teaching And Research (STAR), Fukushima Medical University, 2-1 Toyochi Kamiyajiro, Shirakawa, Fukushima 961-0005, Japan 
b Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan 
c Department of General and Emergency Medicine, JR Tokyo General Hospital, 2-1-3, Yoyogi, Shibuya-ku, Tokyo 151-8528, Japan 
d Department of Health Services Research, Faculty of Medicine, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba, Ibaraki 305-8575, Japan 
e Department of General Practice, Kaita Hospital, 1061-1 Kuchinohara, Iizuka, Fukuoka 820-1114, Japan 
f Department of Nephrology/Clinical Research Support Office, Iizuka Hospital, 3-83 Yoshio-machi, Iizuka, Fukuoka 820-8505, Japan 
g Department of General Medicine, Kimitsu Chuo Hospital, 1010 Sakurai, Kisarazu, Chiba 292-0822, Japan 
h Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba 260-8670, Japan 
i Department of Radiology, Chiba University Hospital, 1-8-1 Inohana, Chiba 260-8677, Japan 
j Department of Radiology, Keiyu Hospital, 3-7-3 Minatomirai, Nishi-ku, Yokohama, Kanagawa 220-8521, Japan 
k Department of Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, 3-4-32 Todaijima, Urayasu, Chiba 279-0001, Japan 
l Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, 54 Shogo-in Kawaramachi, Sakyo-ku, Kyoto 606-8507, Japan 

Corresponding author at: Department of General Medicine, Shirakawa Satellite for Teaching And Research (STAR), Fukushima Medical University, 2-1 Toyochi Kamiyajiro, Shirakawa, Fukushima 961-0005, Japan.Department of General MedicineShirakawa Satellite for Teaching And Research (STAR)Fukushima Medical University2-1 Toyochi KamiyajiroShirakawaFukushima961-0005Japan

Abstract

Background

In most surgical textbooks, it has been stated that pain almost always precedes vomiting in patients with appendicitis. However, the usefulness of this classic history item, “pain before vomiting”, has been investigated in only one study nearly 50 years ago, in which the cause of abdominal pain could not be identified in more than 40% of patients. Accordingly, our objective was to evaluate the performance of pain before vomiting for the diagnosis of acute appendicitis in patients who presented with both acute abdominal pain and vomiting.

Methods

A retrospective chart review of adult outpatients with abdominal pain and vomiting at three acute care hospitals was performed. The reference standard for appendicitis was a CT scan evaluated by two radiologists. Diagnostic performance of pain before vomiting and the value it added to the Alvarado score were evaluated.

Results

Among 310 patients, 24 patients were diagnosed with appendicitis. Diagnostic performance of pain before vomiting was a sensitivity of 95.8% (95% confidence interval [CI] 79.8–99.3) and a specificity of 16.6% (95% CI 12.6–21.4). When combined with the Alvarado score, it ruled out appendicitis in an additional 12% (increased from 32% to 44%) of patients without any false negatives.

Conclusions

“Pain before vomiting” is useful for ruling out appendicitis in patients with abdominal pain and vomiting.

El texto completo de este artículo está disponible en PDF.

Highlights

Diagnostic performance of pain before vomiting for appendicitis is unstudied.
The sensitivity of pain before vomiting for the diagnosis of appendicitis is 96%.
In patients with abdominal pain and vomiting, its use can rule out appendicitis.
With the Alvarado score, it can exclude appendicitis in an additional 12% of patients.

El texto completo de este artículo está disponible en PDF.

Keywords : Clinical decision making, Appendicitis, History taking, Alvarado score

Abbreviations : STARD, CT, LR−, LR+, PPV, NPV, DOR, CI, IQR


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Vol 41

P. 84-89 - mars 2021 Regresar al número
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