Elevated plasma sTIM-3 levels in patients with severe COVID-19 - 09/01/21
, Lars Heggelund, MD, PhD d, e, Andreas Lind, MD, PhD f, Aleksander R. Holten, MD, PhD g, Kristian Tonby, MD, PhD h, Annika E. Michelsen, PhD a, b, Synne Jenum, MD, PhD h, Marthe J. Jørgensen, PhD b, h, Andreas Barratt-Due, MD, PhD g, Linda G. Skeie, RN h, Ingvild Nordøy, MD, PhD a, l, Mai Sasaki Aanensen Fraz, MD a, Else Quist-Paulsen E, MD, PhD b, f, Søren E. Pischke, MD, PhD g, j, Simreen K. Johal, MD f, Liv Hesstvedt, MD, PhD h, Mette Bogen, MSc k, Børre Fevang, MD, PhD a, i, Bente Halvorsen, PhD a, b, Fredrik Müller, MD, PhD b, f, Gry Kloumann Bekken, MD, PhD e, Tom E. Mollnes, MD, PhD c, j, l, m, Susanne Dudman, MD, PhD b, f, Pål Aukrust, MD, PhD a, b, c, i, Anne M. Dyrhol-Riise, MD, PhD b, h, Jan C. Holter, MD, PhD b, f
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
Artículo gratuito.
Conéctese para beneficiarse!
Abstract |
Background |
The pathogenesis of coronavirus disease 2019 (COVID-19) is still incompletely understood, but it seems to involve immune activation and immune dysregulation.
Objective |
We examined the parameters of activation of different leukocyte subsets in COVID-19–infected patients in relation to disease severity.
Methods |
We analyzed plasma levels of myeloperoxidase (a marker of neutrophil activation), soluble (s) CD25 (sCD25) and soluble T-cell immunoglobulin mucin domain-3 (sTIM-3) (markers of T-cell activation and exhaustion), and sCD14 and sCD163 (markers of monocyte/macrophage activation) in 39 COVID-19–infected patients at hospital admission and 2 additional times during the first 10 days in relation to their need for intensive care unit (ICU) treatment.
Results |
Our major findings were as follows: (1) severe clinical outcome (ICU treatment) was associated with high plasma levels of sTIM-3 and myeloperoxidase, suggesting activated and potentially exhausted T cells and activated neutrophils, respectively; (2) in contrast, sCD14 and sCD163 showed no association with need for ICU treatment; and (3) levels of sCD25, sTIM-3, and myeloperoxidase were inversely correlated with degree of respiratory failure, as assessed by the ratio of Pao2 to fraction of inspired oxygen, and were positively correlated with the cardiac marker N-terminal pro-B–type natriuretic peptide.
Conclusion |
Our findings suggest that neutrophil activation and, in particular, activated T cells may play an important role in the pathogenesis of COVID-19 infection, suggesting that T-cell–targeted treatment options and downregulation of neutrophil activation could be of importance in this disorder.
El texto completo de este artículo está disponible en PDF.Key words : COVID-19, outcome, T cell, TIM-3, neutrophil
Abbreviations used : COVID-19, eGFR, Fio2, hsCRP, ICU, NT-proBNP, OUH, P/F ratio, s, sTIM-3
Esquema
| This project has received a private donation from Vivaldi Invest A/S, which is owned by Jon Stephenson von Tetzchner, and has also received funding from COVID-19 Emergency Call for Proposals: Collaborative and Knowledge-building Projects for the Fight Against Coronavirus Disease (COVID-19) from the Research Council of Norway (grant no. 312780). |
|
| Disclosure of potential conflict of interest T. E. Mollnes is a medical advisor for Ra Pharmaceutical, which produces complement inhibitors. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 147 - N° 1
P. 92-98 - janvier 2021 Regresar al número
Artículo precedente
- Compartmental immunophenotyping in COVID-19 ARDS: A case series
- Andreas Ronit, Ronan M.G. Berg, Jakob T. Bay, Anna K. Haugaard, Magnus G. Ahlström, Kristoffer S. Burgdorf, Henrik Ullum, Sara B. Rørvig, Klaus Tjelle, Nicolai B. Foss, Thomas Benfield, Hanne Vibeke Marquart, Ronni R. Plovsing
- COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency department
- Mathias Van Singer, Thomas Brahier, Michelle Ngai, Julie Wright, Andrea M. Weckman, Clara Erice, Jean-Yves Meuwly, Olivier Hugli, Kevin C. Kain, Noémie Boillat-Blanco
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.