Characterization of biopsy proven non-alcoholic fatty liver disease in healthy non-obese and lean population of living liver donors: The impact of uric acid - 03/09/20
, Saman Nikeghbalian, Bita Geramizadeh, Kourosh Kazemi, Alireza Shamsaeefar, Seyed Ali Malek-HosseiniBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Highlights |
• | Biopsy proven NAFLD in metabolically healthy non-obese and lean individuals has not been well characterized. |
• | NAFLD diagnosed by liver biopsy is prevalent in healthy lean individuals. |
• | Higher body mass index and uric acid are risk factors of NAFLD in lean individuals. |
Summary |
Background |
Non-alcoholic fatty liver disease (NAFLD) is frequently seen among non-obese overweight individuals and lean subjects (those with normal body mass index). This study aimed to investigate prevalence and risk factors of biopsy proven NAFLD in a cluster of healthy non-obese and lean individuals.
Methods and Materials |
In a retrospective study, adult (>18 years) apparently healthy individuals who had donated liver to pediatric patients between July 2012 and October 2018 were included. Non-obese and lean individuals were defined as BMI<30kg/m2 and BMI<25kg/m2, respectively.
Results |
Totally 310 patients were included. Seventy-six individuals (24.5%) had NAFL and 30 patients (9.67%) had non-alcoholic steatohepatitis (NASH) among non-obese population. In multivariate regression analysis, only higher BMI was marginally associated with NASH in non-obese compared to those without NASH (Odds ratio: 2.52, 95% CI: 0.097–6.54; P=0.05). Totally, 246 individuals were lean. 55 individuals (22.3%) had NAFL and 20 individuals (8.2%) had NASH in their liver biopsies. In univariate analysis, serum triglyceride, cholesterol, LDL, ALT, alkaline phosphatase and uric acid were associated with NAFL among lean individuals (P<0.05). In regression analysis, serum uric acid was associated with NAFL (Odds ratio: 1.70, 95% CI: 1.18–2.45; P=0.004) and NASH in lean individuals (Odds ratio: 1.98, 95% CI: 1.27–3.10; P=0.003).
Conclusion |
NAFLD/NASH is prevalent even in a healthy lean population when evaluated by liver biopsy. Higher BMI and serum uric acid were two major risks of NAFLD/NASH in non-obese and lean individuals.
El texto completo de este artículo está disponible en PDF.Keywords : Non-alcoholic fatty liver disease, Lean individuals, Non-alcoholic steatohepatitis, Liver biopsy
Abbreviations : NAFLD, NASH, BMI, AST, ALT
Esquema
Vol 44 - N° 4
P. 572-578 - septembre 2020 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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