Impact of ultra-low dose CT acquisition on semi-automated RECIST tool in the evaluation of malignant focal liver lesions - 29/07/20
, J. Frandon, A. Larbi, J. Goupil, H. De Forges, J.-P. Beregi, J. Greffier
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Highlights |
• | Dosimetric values are significantly reduced by more than 50% with ultra-low dose CT protocol compared to standard dose CT protocol. |
• | Semi-automated RECIST tool shows good performances using an ultra-low dose CT protocol. |
• | Semi-automated RECIST tool can be used in routine with an ultra-low dose CT protocol for the follow-up of patients with known malignant focal liver lesions. |
Abstract |
Purpose |
To compare the evaluation of malignant focal liver lesions (FLLs) using a semi-automated RECIST tool with a standard and an ultra-low dose (ULD) computed tomography (CT) protocol.
Materials and methods |
Thirty-four patients with malignant FLLs underwent two abdominal-pelvic CT examinations one using a standard protocol and one using an ULD protocol. There were 23 men and 11 women with a mean age 64.3±14.4 (SD) years (range: 22–91 years). Dosimetric indicators were recorded, and effective dose was calculated for both examinations. Mean malignant FLL attenuation, image noise and contrast-to-noise-ratio (CNR) were compared. The largest malignant FLL per patient was evaluated using the semi-automated RECIST tool to determine longest axis length, longest orthogonal axis length, volume and World Health Organisation area.
Results |
Dosimetric values were significantly reduced by −56% with ULD compared to standard protocol. No differences in mean malignant FLL attenuation values were found between the two protocols. Image noise was significantly increased for all locations (P<0.05) with ULD compared to standard protocol, and CNR was significantly reduced (P<0.05). On the 34 malignant FLLs analyzed, six semi-automated shapes non-concordant with radiologist's visual impression were highlighted with the software, including one FLL (1/34; 3%) with standard CT acquisition only, three FLLs (3/34; 9%) with ULD CT acquisition only and two FLLs (2/34; 6%) with both CT acquisitions. After manual editing, the concordance of the values of the studied criteria between both acquisitions was good and no significant difference was reported.
Conclusion |
Semi-automated RECIST tool demonstrates good performances using ULD CT protocol. It could be used in routine clinical practice with a ULD protocol for follow-up studies in patients with known malignant FLL.
El texto completo de este artículo está disponible en PDF.Keywords : Liver, Computed X-ray tomography, Artificial intelligence, Response evaluation criteria in solid tumours (RECIST), Low dose CT protocol
Abbreviations : BMI, CNR, CI, CT, CTDIvol, DLP, ED, EASL, FLL, HU, IR, iRECIST, mAseff, mRECIST, MRI, R, RECIST, ROI, SAFIRE, SD, ULD, WHO
Esquema
Vol 101 - N° 7-8
P. 473-479 - juillet 2020 Regresar al número
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