Intravoxel incoherent motion MRI for the initial characterization of non-fatty non-vascular soft tissue tumors - 25/03/20
, L. Simon a, F. Sirveaux b, B. Marie c, M. Louis a, G. Hossu d, A. Blum a
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Abstract |
Purpose |
To compare the capabilities of intravoxel incoherent motion (IVIM) to those of monoexponential diffusion-weighted imaging for differentiating benign from malignant non-vascular, non-fatty soft tissue tumors (NVSFSTT).
Material and methods |
A total of 64 patients with 64 histologically confirmed soft-tissue tumors were retrospectively included. There were 23 men and 41 women with a mean age of 52±17 (SD) (range: 18–92 years). IVIM parameters, including molecular diffusion restriction coefficient (ADCtrue), perfusion fraction, and tissue perfusion related coefficient were compared to mean monoexponential ADC (ADCstd) values. Two readers calculated all parameters, which were compared to histopathological findings that were used as standard of reference.
Results |
The overall performance of ADCtrue and ADCstd was similar for the benign-malignant differentiation of NFNVSTT with accuracies ranging from 73% to 75% for both readers (P=0.3). Interobserver reproducibility was considered excellent for both ADCstd and all IVIM parameters (ICC=0.81–0.96). When myxoid tumors were excluded from morphological analysis, an increase in sensitivity of 16–21% of ADCtrue was observed, with no changes in specificity values. The use of perfusion related IVIM parameters in association with ADCtrue did not improve tumor characterization.
Conclusion |
The use of IVIM parameters does not improve the characterization of NVNFSTT by comparison with conventional monoexponential ADC calculation.
El texto completo de este artículo está disponible en PDF.Keywords : Intravoxel incoherent motion (IVIM), Diffusion Magnetic Resonance Imaging, Soft Tissue Neoplasms, Comparative study
Abbreviations : NVNFSTT, DWI, IVIM, ADC, ADCavg, ADCstd, ADCtrue, D*, f, ROI, FSE, NEX, FOV, ICC
Esquema
Vol 101 - N° 4
P. 245-255 - avril 2020 Regresar al número
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