Correlation of Circulating miR-765, miR-93-5p, and miR-433-3p to Obstructive Coronary Heart Disease Evaluated by Cardiac Computed Tomography - 15/06/19
, Ernesto Forte, BME a, 1, Bruna Punzo, RTD a, Filippo Cademartiri, MD, PhD a, Carlo Cavaliere, MD a, Andrea Soricelli, MD a, b, Marco Salvatore, MD a, Claudio Napoli, MD, PhD, MBEth a, cResumen |
Epigenetic-sensitive mechanisms may be correlated both to pathogenesis and prognosis of coronary heart disease (CHD). We prospectively investigated some plasma circulating microRNA levels in patients undergoing cardiac computed tomography for suspected CHD (n = 95).
We show that let-7c-5p, miR-765, miR-483-5p, miR-31-5p, and miR-206 were upregulated in CHD patients (n = 66) versus healthy subjects HS (n = 29); moreover, let-7c-5p, miR-765, miR- 483-5p showed higher expression in obstructive CHD (n = 36) compared to no obstructive CHD patients (n = 66). Remarkably, miR-765, miR-93-5p, and miR-433-3p showed an upregulation in patients with critical coronary stenosis. Multivariate regression analysis demonstrated that miR-765, miR-31-5p, and miR-206 were independently associated with CHD while circulating levels of miR-765 (p = 0.035), miR-433-3p (p = 0.043), and miR-93-5p (p = 0.041) were significantly higher in critical stenosis patients. Receiver operating characteristic curve analysis revealed a good performance for miR-765, miR-93-5p, and miR-433-3p on predicting CHD severity. In conclusion, our study represents a combined epigenetic/imaging approach useful to support the diagnosis and prediction of CHD.
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| Funding: This study was supported by Italian Ministry of Health grants: “Giovani Ricercatori 2011-12” (project code GR-2011-02349436) (T.I.) and “Ricerca Corrente 2018” (C.N). |
Vol 124 - N° 2
P. 176-182 - juillet 2019 Regresar al número
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