Predictive factors of upstaging DCIS to invasive carcinoma in BCT vs mastectomy - 24/05/19
Abstract |
Background |
Upstaging from DCIS to invasive ductal carcinoma varies widely from 0 to 59%. We aim to identify risk factors associated with upstaging in all DCIS patients and based on specific surgical intervention.
Methods |
Patients with a pre-operative diagnosis of DCIS undergoing BCT or mastectomy were reviewed. Multivariable analysis was performed to identify risk factors for upstaging.
Results |
In total, 623 patients had a preoperative diagnosis of DCIS. Upstaging occurred in 74 patients (12%) overall. There was no difference in upstaging rates between mastectomy and BCT (11% v 14% p = 0.27). Sentinel lymph node biopsy was positive in 4/212 patients (1%). Multivariable analysis revealed suspicion of microinvasion (OR 5.7 95%CI2.2–14.9), surgeon suspicion of invasive disease (OR 2.7, 95% CI 1.2–6.4) and larger size/multicentric/extensive tumor (OR 1.9 95% CI 1.1–3.4) increase risk of upstaging.
Conclusions |
Suspicion of microinvasion, surgeon suspicion, and tumor size can be used to help guide the use of sentinel lymph node biopsy. For patients without these high risk characteristics, it is hard to justify the use of concurrent SLN biopsy for patients who undergo BCT.
El texto completo de este artículo está disponible en PDF.Highlights |
• | Suspicion of microinvasion, surgeon suspicion, and tumor size can guide the use of sentinel lymph node biopsy. |
• | It is hard to justify sentinel lymph node biopsy in BCT patients without these high risk characteristics. |
• | Suspicion of microinvasion is associated with a 50% upstage rate to invasive ductal carcinoma. |
Esquema
Vol 217 - N° 6
P. 1025-1029 - juin 2019 Regresar al número
Artículo precedente
- Outcomes following laparoscopic Roux-en-Y gastric bypass (LRYGB) vary by sex: Analysis of 83,059 women and men with morbid obesity
- Malinda Lyon, Chris Bashian, Casey Sheck, Leon Kushnir, Gus J. Slotman
- Determining the impact of culture on venous thromboembolism prevention in trauma patients: A Southwestern Surgical Congress Multicenter trial
- Justin L. Regner, Courtney N. Shaver
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
¿Ya suscrito a @@106933@@ revista ?