Reduction of lymphocele rate in patients undergoing sentinel node biopsy for melanoma by intraoperative placement of plant-based hemostatic powder: Results of a prospective trial - 16/04/19
Abstract |
Background |
Lymphocele is a complication of sentinel node biopsy (SNB) for melanoma. Plant-based hemostatic powder (PBHP) may have a lymphostatic benefit. We studied whether PBHP placed intraoperatively could reduce lymphocele rates.
Methods |
We performed an open label, prospective, IRB -approved, before- and-after, matched control trial of PBHP placed into the wound in patients undergoing SNB of groin or axillary nodes for melanoma staging. Patient/tumor features and lymphocele rates were compared by standard statistical tests.
Results |
66 control and 66 treatment (49 axillary and 17 groin in each arm) SNBs were performed in 61 and 55 patients, respectively, for a total 132 SNBs in 116 patients. Patient and tumor features were similar between groups. Nineteen lymphoceles occurred (14.4%); lymphocele rates were 22.2% (14/66) in the control group and 7.6% (5/66) in the treatment group (p = 0.026). The reduction in lymphocele rates between arms was greater for axillary than for groin sites (87.5% vs. 33%); the axillary reduction was statistically significant (p = 0.030).
Conclusions |
Intra-operative placement of PBHP reduced the rate of lymphoceles in patients undergoing SNB for melanoma.
El texto completo de este artículo está disponible en PDF.Highlights |
• | Lymphocele remains a common occurrence in sentinel node biopsy (SNB) for melanoma. |
• | We performed a prospective, matched control trial of plant-based hemostatic powder (PBHP) placed into the SNB wound. |
• | Intra-operative placement of PBHP reduced the rate of lymphoceles. |
Keywords : Melanoma, Lymphocele, Plant-based hemostatic powder, Prospective trial, Reduction
Esquema
Vol 217 - N° 5
P. 878-881 - mai 2019 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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