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Optimizing patient referral and center capacity in the management of chronic hepatitis C: Lessons from the Italian experience - 03/04/19

Doi : 10.1016/j.clinre.2018.09.007 
Alfredo Alberti a, , Gioacchino Angarano b , Massimo Colombo c , Antonio Craxì d , Vito Di Marco d , Giovanni Di Perri e , Giovanni Battista Gaeta f , Giuseppe Ippolito g , Alessandra Mangia h , Patrizio Pasqualetti i
a Dipartimento di Medicina Molecolare, Università di Padova, Padova, Italy 
b Unità Operativa di Malattie Infettive, Azienda Ospedaliera “Ospedale Policlinico Consorziale” Università di Bari, Bari, Italy 
c Centro di Ricerca Traslazionale in Epatologia, Humanitas Research Hospital, Rozzano, Italy 
d Sezione di Gastroenterologia & Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy 
e Clinica di Malattie Infettive, Dipartimento di Scienze Mediche, Università degli Studi di Torino, Torino, Italy 
f UOC Malattie Infettive ed Epatiti Virali, Università della Campania Luigi Vanvitelli, Napoli, Italy 
g Istituto Nazionale per le Malattie Infettive, IRCCS, Lazzaro Spallanzani, Roma, Italy 
h Unità Operativa Complessa di Epatologia dell’Ospedale “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy 
i Fondazione Fatebenefratelli per la Ricerca e la Formazione Sanitaria e Sociale, Roma, Italy 

Corresponding author at: Department of Molecular Medicine, University of Padova, Via Giustiniani 2, 35100 Padova, Italy.Department of Molecular Medicine, University of PadovaVia Giustiniani 2Padova35100Italy

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Highlights

Italian Health Authorities instigated programs to eradicate HCV in 2017.
Delphi study identified, improved patient referral, increased role of GPs, greater capacity in Clinical Centers, improved management of high-risk groups and liaison between healthcare professionals, as priorities to meet targets.

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Abstract

Aims

In 2017 the Italian Drug Agency (Agenzia Italiana del Farmaco, AIFA) revised the criteria for access to therapy for patients with chronic hepatitis C as part of a three-year plan to eradicate HCV. We conducted a Delphi study to determine strategies to identify and treat patients with HCV and to develop through a shared pathway, a model to manage patient referral and optimize prescription center capacity with the overall aim of increasing access to therapy.

Methods

The process took place in two phases – Phase I (January 2017), before the criteria for treatment of HCV were revised and Phase II (May 2017) when AIFA developed a framework for the eradication of HCV infection in Italy. Two questionnaires were devised with Q1 administered in Phase I and Q2 in Phase II.

Results

Q1 was sent to 823 hepatitis specialists working in 235 Italian HCV centers authorized to prescribe direct-acting antiviral drugs (DAAs). Overall, 167 centers (71%) participated with a good geographical representativeness (North 69%, Centre 74%; South and islands 70%). 548 prescribers (68.8%) provided responses to Q1 and 443 (80%) specialists who responded to Q1 completed Q2. Over 70% considered that to meet the new therapy targets local/regional networks need to be consolidated and reinforced with GPs providing the ‘missing link’ in current regional networks. Adherence to therapy was considered important by 75% of clinicians with reduction in follow-up intervals/length considered important by 65% – to free up staff/resources to manage increasing numbers of new patients. About 80% of respondents stated that medical personnel were principally involved in follow-up with follow-up having a significant impact on center capacity.

Conclusion

Enhancing patient referral, the need for an increased role of GPs, increasing center capacity in particular medical personnel in outpatient centers and greater liaison between Hub centers and healthcare professionals currently managing high-risk groups as yet untreated, were factors that need to be streamlined in order to meet treatment targets for eradication of HCV.

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Keywords : Hepatitis C virus, direct-acting antivirals, Delphi method, disease eradication


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© 2018  The Authors. Publicado por Elsevier Masson SAS. Todos los derechos reservados.
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Vol 43 - N° 2

P. 190-200 - avril 2019 Regresar al número
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