Fillers and toxins are safe, quick, and require no downtime; the immediately visible results can boost a man’s self-esteem, confidence, youthfulness, and sense of competitiveness in the personal and professional realms of the world. The approach to using these agents has changed from ironing out the skin to remove wrinkles and lines to a restructuring of the 3-dimensional face. This new strategy, volumetric structural rejuvenation (VSR), relies on intimate knowledge of facial anatomy and the pathophysiology of aging. It is of essence to know the key anatomic differences between the 2 sexes to avoid potential feminization.