Arthroscopic bankart surgery: Does gabapentin reduce postoperative pain and opioid consumption? A triple-blinded randomized clinical trial - 16/08/16

Doi : 10.1016/j.otsr.2016.01.028

M. Mardani-Kivi ^a,^⁎ , M. Karimi Mobarakeh ^b, S. Keyhani ^c, M. Haghighi ^d, K. Hashemi-Motlagh ^e, K. Saheb-Ekhtiari ^e
^a Orthopedic Department, Guilan Road Trauma Center, Guilan University of Medical Sciences, Poursina Hospital, Rasht, Iran
^b Orthopedic Department, Kerman University of Medical Sciences, Kerman, Iran
^c Orthopedic Surgery, Shahid Beheshti University of Medical Sciences, Akhtar Orthopedic Hospital, Tehran, Iran
^d Anesthesiology Department, Guilan University Of Medical Sciences, Rasht, Iran
^e Orthopedic Research Center, Guilan University of medical sciences, Rasht, Iran

^⁎Corresponding author at: Tel.: +981313211470; fax: +981333311178.

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Abstract

Background

The role of gabapentin as preemptive analgesia in managing acute pain following shoulder bankart arthroscopy is controversial and the studies addressing this issue are limited.

Hypothesis

The present study was undertaken to examine the effects of preemptive single dose of gabapentin on pain management and opioid consumption in patients undergoing arthroscopic bankart surgery.

Patients and methods

In the current triple-blinded randomized clinical trial, 76 eligible patients were randomly divided into two groups either taking gabapentin 600mg (G group) or placebo (P group). The primary outcomes were pain intensity assessed based on Visual Analogue Scale (VAS) and secondary outcomes were opioid consumption and side effects, dizziness, sedation, nausea and vomiting at 6h and 24h follow-up visits.

Results

The pain intensity were not significantly different between the G and P groups (P>0.05). The opioid consumption, however, was significantly reduced in G group at both 6h and 24h follow-up visits (P<0.001). Dizziness and sedation were similar in both groups. Nausea and vomiting were significantly lower in G group only at 6h visit but similar at 24h follow-up visit (P<0.001).

Discussion

The preemptive single dose of gabapentin 600mg administered prior to arthroscopic bankart surgery does not decrease post-operation pain, but reduces opioid consumption. Gabapentin restrained postoperative nausea and vomiting for a short while (less than 6h).