Prenatal exposure profiles to parabens and their impacts on thyroid hormones - 26/10/24

Doi : 10.1016/j.toxac.2024.09.018

Abderrezak Khelfi ^a,^b,^⁎ , Melissa Samer ^a, Lyece Yargui ^a,^c, Youcef Tayebi ^d,^e, Lounas Benghanem ^a,^f, Amel Dammene-Debbih ^a,^g, Fadila Madaci ^a,^h, Mohamed Azzouz ^a
^a University of Algiers 1, 2 Didouche Mourad Street, 16000 Algiers, Algeria
^b National Center of Toxicology, Petit Staouali Street, Delly Brahim, 16062 Algiers, Algeria
^c Biochemistry laboratory, Mustapha Bacha University Hospital, 1945 Pl. of May 1st, Sidi M’Hamed Street, 16000 Algiers, Algeria
^d University of Blida, BP 270, 09000 Blida, Algeria
^e Obstetrics and gynecology Department, Douera University Hospital, Halim Brothers Street, Douera, 16000 Algiers, Algeria
^f Obstetrics and Gynecology Department, Mustapha Bacha University Hospital, 1945 Pl. of May 1st, Sidi M’Hamed Street, 16000 Algiers, Algeria
^g Obstetrics and Gynecology Department, Ibn Ziri Hospital, Bainem, 16000 Algiers, Algeria
^h Obstetrics and Gynecology Department, Bab-El-Oued University Hospital, Mohamed-Lamine-Debaghine Street, 16009 Algiers, Algeria

^⁎Corresponding author: University of Algiers 1, 2 Didouche Mourad Street, 16000 Algiers, Algeria.University of Algiers 12 Didouche Mourad StreetAlgiers16000Algeria

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Saturday 26 October 2024

Summary

Backgrounds

Parabens, often suspected of being endocrine disrupting chemicals (EDCs), are commonly used as antimicrobial preservatives in many products (personal care products, food, and pharmaceutical products). Exposure to these substances during pregnancy could disrupt thyroid hormone homeostasis and potentially affect fetal growth.

Objectives

The aim of this study was to identify paraben exposure profiles in the umbilical cord and to assess the impact of these substances on thyroid hormones in women giving birth. In addition, this work evaluates the potential link between possible sources of exposure and endogenous paraben concentrations.

Material and methods

A total of 154 pregnant women living in Algiers were recruited. Umbilical cord venous blood samples were taken immediately after delivery. Thyroid hormones (TSH, FT3, and FT4) were measured by electrochemiluminiscence. Parabens (MP, EP, and PP) were detected and determined by LC-MS/MS.

Results

MP, EP, and PP were detected in 88.31%, 74.02%, and 85.06% of samples with mean concentrations of 1.42±1.08ng/mL for MP, 1.19±1.19ng/mL for EP, and 1.40±1.30ng/mL for PP. Exposure to EP was associated with an increase in TSH and a decrease in FT3 levels, whereas PP exposure was associated with a decrease in TSH and FT4 levels. Linear regression results showed several significant associations between paraben levels and general characteristics of newborns (gestational age, birth weight, and AGD in male). Analysis of potential sources of exposure to endocrine disruptors revealed a significant association between MP and EP concentrations and coffee consumption. A significant association was observed between EP levels and sunscreen use, and between PP levels and the use of Paraben-free shower gel. Finally, significant associations were observed between some household sources and parabens.