Serum ubiquitin C-terminal hydrolase L1 as a biomarker for traumatic brain injury: a systematic review and meta-analysis - 04/09/15
Abstract |
Objective |
Serum ubiquitin C-terminal hydrolase L1 (UCH-L1) has been proposed as a biomarker of traumatic brain injury (TBI). However, previous studies on levels of UCH-L1 in serum remain inconsistent. This systematic review and meta-analysis were conducted on observational studies that reported the association between serum UCH-L1 levels and TBI.
Methods |
Studies were identified by searching PubMed and ISI Web of Science up to February 2015. For the continuous outcomes, we calculated the weighted mean difference and 95% confidence interval. The statistical analysis was performed by RevMan 5.1 and Stata 12 software. Only case-control studies were included if they had data on serum UCH-L1 levels in TBI patients and healthy controls. Funnel plot and Egger's regression test were applied to assess the potential publication bias.
Results |
Of the 145 selected studies, 11 observational studies (including 9 case-control and 2 case-crossover studies) met the selection criteria, containing a total of 1138 TBI cases and 1373 controls. Finally, 5 case-control studies (including 673 TBI and 1004 controls) were eligible for the present meta-analysis. The results of our study showed that there was a significant increase in serum UCH-L1 levels in patients with TBI compared to controls (weighted mean difference, 0.96; 95% confidence interval, 0.31-1.61; P = .004).
Conclusion |
In conclusion, TBI cases had higher serum UCH-L1 concentrations than matched controls. This reinforces the conceptualization of UCH-L1 as a potential biomarker of TBI.
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☆ | Funding: This work was supported by the National Natural Science Foundation of China (no. 61302030) and the Educational Commission of Liaoning Province of China (no. L2012320). |
☆☆ | Competing interests: The authors have declared that no competing interests exist. |
★ | Contributors: JL and YYL conceived and designed the experiments. JL, CY, and YS performed the experiments. JL, CY, and YS analyzed the data. JL and YYL wrote the manuscript. |
Vol 33 - N° 9
P. 1191-1196 - septembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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