Gray Matter Volume Decrease Distinguishes Schizophrenia From Bipolar Offspring During Childhood and Adolescence - 24/07/15
, Elena de la Serna, PhD b, Soledad Romero, MD, PhD b, Vanessa Sanchez-Gistau, MD, PhD c, Anna Calvo, MSc e, Dolores Moreno, MD, PhD f, Inmaculada Baeza, MD, PhD c, Covadonga M. Diaz-Caneja, MD g, Teresa Sanchez-Gutierrez, PhD g, Joost Janssen, PhD f, Nuria Bargallo, MD, PhD h, Josefina Castro-Fornieles, MD, PhD c, dAbstract |
Objective |
There is increasing support toward the notion that schizophrenia and bipolar disorder share neurodevelopmental underpinnings, although areas of divergence remain. We set out to examine gray matter volume characteristics of child and adolescent offspring of patients with schizophrenia or bipolar disorder comparatively.
Method |
In this 2-center study, magnetic resonance structural neuroimaging data were acquired in 198 children and adolescents (aged 6-17 years): 38 offspring of patients with schizophrenia, 77 offspring of patients with bipolar disorder, and 83 offspring of community controls. Analyses of global brain volumes and voxel-based morphometry (using familywise error correction) were conducted.
Results |
There was an effect of group on total cerebral gray matter volume (F = 3.26, p = .041), driven by a decrease in offspring of patients with schizophrenia relative to offspring of controls (p = .035). At a voxel-based level, we observed an effect of group in the left inferior frontal cortex/anterior insula (F = 14.7, p < .001), which was driven by gray matter volume reduction in offspring of patients with schizophrenia relative to both offspring of controls (p = .044) and of patients with bipolar disorder (p < .001). No differences were observed between offspring of patients with bipolar disorder and offspring of controls in either global or voxel-based gray matter volumes.
Conclusion |
This first comparative study between offspring of patients with schizophrenia and bipolar disorder suggests that gray matter volume reduction in childhood and adolescence may be specific to offspring of patients with schizophrenia; this may index a greater neurodevelopmental impact of risk for schizophrenia relative to bipolar disorder during youth.
Le texte complet de cet article est disponible en PDF.Key Words : schizophrenia, bipolar disorder, magnetic resonance imaging
Plan
| Funding for this study was provided by the Spanish Ministry of Economy and Competitiveness/Instituto de Salud Carlos III (FIS PI 07/0066, PI 11/00683)/European Regional Development Fund, La Marató de TV3 Foundation (091630), Catalonia Government (2009SGR1119), and Madrid Regional Government (S2010/BMD-2422 AGES). |
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| Disclosure: Dr. Sugranyes has received research funding from the Spanish Ministry of Economy and Competitiveness (MINECO)/Instituto de Salud Carlos III (ISCIII) and the Alicia Koplowitz Foundation. She has also received travel support from Otsuka. Dr. Romero has received research funding from the MINECO/ISCII and the Alicia Koplowitz Foundation. Dr. Sanchez-Gistau has received travel support from Otsuka. Dr. Moreno has received research funding from the MINECO/ISCII and the Madrid Regional Government. Dr. Baeza has received research funding from the MINECO/ISCII, the Alicia Koplowitz Foundation, and the Biomedical Research Networking Center Consortium (CIBER; CCSM). She has also received travel support from Otsuka. Dr. Díaz-Caneja has held a Río Hortega grant from the MINECO/ISCII and from the Alicia Koplowitz Foundation. Dr. Bargalló has received research funding from the MINECO/ISCII and from La Marató de TV3 Foundation. Dr. Castro-Fornieles has received research funding from the Catalonia Government, the European Union's 7th Framework Programme, the MINECO/ISCII, La Marató de TV3 Foundation, Agrupació Mútua Foundation, and CCSM. Drs. de la Serna, Sanchez-Gutierrez, Janssen, and Ms. Calvo report no biomedical financial interests or potential conflicts of interest. |
Vol 54 - N° 8
P. 677 - août 2015 Retour au numéro
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