Granulomatous Drug Eruptions - 03/07/15

Doi : 10.1016/j.det.2015.03.015

Roni P. Dodiuk-Gad, MD ^a,^b, Neil H. Shear, MD, FRCPC ^a,^c,^⁎
^a Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M1-737, Toronto, ON M4N 3M5, Canada
^b Department of Dermatology, Ha’emek Medical Center, Afula 18101, Israel
^c Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room M1-737, Toronto, Ontario M4N 3M5, Canada

^∗Corresponding author. Dermatology Division, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room M1-737, Toronto, Ontario M4N 3M5, Canada.

Résumé

Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a granulomatous reaction pattern are rare, and defined by a predominance of histiocytes in the inflammatory infiltrate. This review summarizes current knowledge on the various types of granulomatous drug eruptions, focusing on the 4 major types: interstitial granulomatous drug reaction, drug-induced accelerated rheumatoid nodulosis, drug-induced granuloma annulare, and drug-induced sarcoidosis.

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Keywords : Granuloma, Drug, Granulomatous drug eruptions, Skin, Noninfectious granuloma

Plan

Conflicts of Interest: The authors have no financial or other conflicts of interest, including financial interests and relationships and affiliations relevant to the subject of this submission.