Has the percutaneous vertebroplasty a role to prevent progression or local recurrence in spinal metastases of breast cancer? - 02/07/15
, Sébastien Touraine b, Evelyne Cormier a, Luc Molet-Benhamou a, Lise Le Jean c, Hervé Brisse b, Sylvia Neuenschwander b, Jacques Chiras aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Summary |
Objective |
To evaluate the effectiveness of percutaneous vertebroplasty (PV) on the prevention of progression or local recurrence in patients with spinal metastases from breast cancer.
Materials and methods |
Retrospective study on 55 patients between 27–78 years of age (mean age: 55years) treated for metastatic breast cancer in the same institution (Curie institute, Paris, France), who underwent percutaneous vertebroplasty (PV) (number of vertebrae treated=137) for spinal metastases from January 2000 to December 2009 at the Pitié-Salpêtrière hospital. Statistical correlation between the local tumor progression/recurrence, and the presence of an epidural or a paravertebral metastatic extension at diagnosis, the rate of cement filling the lesion (<50%, ≥50% but incomplete, complete/almost complete) and radiotherapy was evaluated using Chi2 and Fisher's exact test.
Results |
The rate of local tumor progression/recurrence of the vertebrae treated by vertebroplasty was 14% (19/137). No statistically significant correlation between either the rate of cement filling of the lesion, or the presence of an epidural or paravertebral metastatic extension, and progression/local recurrence after vertebroplasty was found. No influence of radiotherapy in preventing local progression/recurrence was noted. Distant new bone metastases were observed in 47 out of 55 patients (86%).
Conclusion |
The low rate of local tumor progression/recurrence after a vertebroplasty may support the hypothesis of an antitumor effect of the cement.
Le texte complet de cet article est disponible en PDF.Keywords : Percutaneous vertebroplasty, Recurrence, Progression, Antitumor effect, Breast cancer, Metastasis
Plan
Vol 42 - N° 4
P. 222-228 - juillet 2015 Retour au numéro
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