Cognitive Functioning of Depressed Patients with History of Suicidal Attempt - 09/06/15
Résumé |
Introduction |
Major Depressive Disorder (MDD) is a complex disease characterized by cognitive dysfunctions. The subgroups of MDD show different cognitive profile.
Aims |
The aim of this study to examine whether depressed suicide attempters show impaired executive functions.
Objectives |
We hypothesised that patients from this subgroup have decision making, cognitive inhibition and verbal working memory deficits.
Methods |
17 depressed patients with history of suicide attempt and 13 healthy subjects completed the reward and punishment-related versions of a decision making task (Iowa Gambling Task, IGT), an irrelevant-respond inhibition task (Stroop Task), a respond inhibition task (Stop Task) and a measure of verbal working memory (Digit Span).
Results |
Depressed patients showed impairment in the reward-related version of IGT (ABCD) and higher error-interference effect in the Stroop Task. There was a tendency toward higher reaction time-interference in Stroop Task and worse performance in Digit Span. Their performance did not differ from healthy controls in the punishment-related version of IGT (EFGH) and in the Stop Task.
Conclusions |
Reward-related decision making, irrelevant-respond inhibition and verbal working memory dysfunctions were more frequently found among the patient group. They perform normally in the punishment-related version of IGT, while preliminary studies show that patients who attempt suicide within 72 hours perform poorly in this task. Further studies should examine whether punishment-related version can differentiate high-risk suicide attempters.
Vol 30 - N° S1
P. 642 - mars 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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