Clozapine in the Treatement of Refractory Bipolar Disorder - 09/06/15
Résumé |
Clozapine is a second-generation antipsychotic, it. has been used in bipolar disorder refractory since 1989. Its use has been shown to reduce symptom severity in patients with manic and mixed-state episodes. The aim of this paper is to systematically review data published in 2014 to evaluate the effectiveness of clozapine in BD
Methods |
the Medline database was searched for 2014 publications using the following keywords: ‘clozapine’; ‘refractory bipolar disorder’; ‘ effectiveness’; ‘ side effects’.
Results |
Medline search returned 110 results. Manual inspection of abstracts allowed selecting six papers for further review.
The first meta-analysis of the efficacy of clozapine in the treatement of refractory bipolar disorder, published in2014,showed the effectiveness and safety of rapid clozapine titration by decreasing the need for psychotropic co-medications, and reducing the number of psychiatric hospitalization. Other papers suggested that this molecule present adverse reaction associated with problems in clinical and biological tolerance which explains its abondan.
Conclusion |
clozapine used at low dose is a molecule of future in the treatment of bipolar disorder and recent publication showed that its side effects join the other second generation antipsychotics
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Vol 30 - N° S1
P. 454 - mars 2015 Retour au numéro
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