Maternal History of Autoimmune Disease and Later Development of Tourette Syndrome in Offspring - 28/05/15
, Berit L. Waltoft, MSc a, c, James F. Leckman, MD, PhD d, Preben Bo Mortensen, MD, DrMedSc eAbstract |
Objective |
In a nationwide prospective cohort study, we examined the possible association between maternal autoimmune disease (AD) and later diagnosis of Tourette syndrome (TS) in offspring.
Method |
Data from national Danish health registers identified a cohort consisting of all children born in Denmark between 1990 and 2007 (n = 1,116,255), followed prospectively from birth until 2011, date of TS diagnosis, death, or emigration/disappearance, whichever came first. The incidence rate ratio (IRR) of TS, dependent on whether or not the mother had a prior diagnosis of AD, was estimated by Poisson regression with 95% CIs and adjusted for age, calendar time, place of birth, maternal and paternal age, parental psychiatric diagnoses other than TS, and parental TS.
Results |
The cohort contributed a total of 13,000,162 person years and 2,442 participants with a diagnosis of TS (414 females and 2,028 males). Prior maternal AD was found in 110 of the 2,442 children with TS, corresponding to an increased risk of TS, with an adjusted IRR of 1.22 (95% CI = 1.01–1.48). Maternal history of a prior AD increased the risk of TS in males, with an adjusted IRR of 1.29 (95% CI = 1.05–1.58), but not in females, with an adjusted IRR of 0.89 (95% CI = 0.52–1.52).
Conclusion |
Maternal AD was associated with a 29% increased incidence rate of TS in male offspring. This finding supports the hypothesis that neuroimmunological disorders may act as a component in the etiology of a subset of TS.
Le texte complet de cet article est disponible en PDF.Key Words : Tourette syndrome, tics, autoimmune disease, neuroimmunology, cohort study
Plan
| This article was reviewed under and accepted by deputy editor John T. Walkup, MD. |
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| The authors are grateful for the supporting funding for this study, including grants from the Lundbeck Foundation, the Wörzner Foundation for Psychiatric Research, the Danish Agency for Science, Technology and Innovation (International Network Grant, 2010 for S.D. and J.F.L.), and the Danish Agency for Science, Technology and Innovation (Visiting Scientist at Yale, 2011 for S.D.). |
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| The authors thank Annette Rand Madsen, Authorized Medical Secretary, Centre Administrator, NCRR, Aarhus University, for proofreading the report. This study was planned by J.F.L., P.B.M., B.L.W., and S.D. Statistical analyses were planned by B.L.W., P.B.M., and S.D., performed by B.L.W., and reviewed by S.D., J.F.L., and P.B.M. The first draft of the manuscript was prepared by S.D. and B.L.W. in collaboration and revised by J.F.L. and P.B.M. All authors approved the final version of the manuscript. B.L.W. and S.D. shared the first-authorship of this article. |
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| Disclosure: Dr. Dalsgaard has served as a consultant to the Danish Health and Medicines Authority. Dr. Leckman has received grant or research support from the National Institute of Mental Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Tourette Syndrome Association, and Grifols, S.A. He has received royalties from John Wiley and Sons, McGraw Hill, and Oxford University Press. He has authored the Yale Global Tic Severity Scale (YGTSS) assessment tool. He has received donations to clinical and research programs by the Associates of the Yale Child Study Center. Dr. Mortensen and Ms. Waltoft report no biomedical financial interests or potential conflicts of interest. |
Vol 54 - N° 6
P. 495 - juin 2015 Retour au numéro
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