High hepatitis E virus seroprevalence with absence of chronic infection in HIV-infected patients - 08/05/15
Summary |
Background & aims |
The seroprevalence of the hepatitis E virus (HEV) and its chronicity rate in the HIV-infected population has not been well established. As a result, the magnitude of this emerging disease in this population cannot be established.
Methods |
Prospective study that included HIV-infected patients followed up between September 2012 and May 2013. All included patients were tested for anti-HEV IgG/IgM. In patients with confirmed anti-HEV IgG/IgM positivity, RT-PCR was performed. In patients where HEV RNA was amplified, a second RT-PCR assay was performed 6 months later to identify transient or chronic HEV infections.
Results |
Eight hundred and ninety-four HIV-infected patients were enrolled in the study. Of these patients, 399 (44.6%) were monoinfected with HIV; 462 (51.6%) were co-infected with HIV/HCV; 12 (1.3%) were co-infected with HIV/HBV; and 21 (2.3%) were co-infected with HIV/HCV/HBV. In 88 patients, anti-HEV IgG/IgM was detected (seroprevalence: 9.8% [95% CI: 8.02%–11.9%]). In five patients (0.5%; 95% CI: 0.2%–1.2%), HEV RNA was detected; 5.7% (95% CI: 2.1%–12.1%) of the patients were anti-HEV IgG/IgM positive. None of these patients showed detectable HEV RNA six months later.
Conclusion |
HEV infection is frequent in HIV-infected patients but developing a chronic HEV infection may be considered an uncommon liver disease in this population.
Le texte complet de cet article est disponible en PDF.Highlights |
• | A prospective analysis of HEV seroprevalence in HIV-infected patients from Spain. |
• | The seroprevalence of IgG anti-HEV was 9.8%, testing 894 patients. |
• | Five patients exhibited serum HEV-RNA+. |
• | None of these five patients showed detectable HEV RNA after six months. |
Keywords : Hepatitis E virus, HIV, Seroprevalence, Anti-HEV IgG, Anti-HEV IgM, HEV RNA
Plan
Vol 70 - N° 6
P. 624-630 - juin 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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