High hepatitis E virus seroprevalence with absence of chronic infection in HIV-infected patients - 08/05/15
, Loreto Martinez-Dueñas a, c, Antonio Martinez-Peinado a, Angela Camacho a, Celia Cifuentes b, Ana Gordon a, Mario Frias a, Julian Torre-Cisneros a, Juan A. Pineda b, Antonio Rivero a, ⁎ Summary |
Background & aims |
The seroprevalence of the hepatitis E virus (HEV) and its chronicity rate in the HIV-infected population has not been well established. As a result, the magnitude of this emerging disease in this population cannot be established.
Methods |
Prospective study that included HIV-infected patients followed up between September 2012 and May 2013. All included patients were tested for anti-HEV IgG/IgM. In patients with confirmed anti-HEV IgG/IgM positivity, RT-PCR was performed. In patients where HEV RNA was amplified, a second RT-PCR assay was performed 6 months later to identify transient or chronic HEV infections.
Results |
Eight hundred and ninety-four HIV-infected patients were enrolled in the study. Of these patients, 399 (44.6%) were monoinfected with HIV; 462 (51.6%) were co-infected with HIV/HCV; 12 (1.3%) were co-infected with HIV/HBV; and 21 (2.3%) were co-infected with HIV/HCV/HBV. In 88 patients, anti-HEV IgG/IgM was detected (seroprevalence: 9.8% [95% CI: 8.02%–11.9%]). In five patients (0.5%; 95% CI: 0.2%–1.2%), HEV RNA was detected; 5.7% (95% CI: 2.1%–12.1%) of the patients were anti-HEV IgG/IgM positive. None of these patients showed detectable HEV RNA six months later.
Conclusion |
HEV infection is frequent in HIV-infected patients but developing a chronic HEV infection may be considered an uncommon liver disease in this population.
Le texte complet de cet article est disponible en PDF.Highlights |
• | A prospective analysis of HEV seroprevalence in HIV-infected patients from Spain. |
• | The seroprevalence of IgG anti-HEV was 9.8%, testing 894 patients. |
• | Five patients exhibited serum HEV-RNA+. |
• | None of these five patients showed detectable HEV RNA after six months. |
Keywords : Hepatitis E virus, HIV, Seroprevalence, Anti-HEV IgG, Anti-HEV IgM, HEV RNA
Plan
Vol 70 - N° 6
P. 624-630 - juin 2015 Retour au numéro
Article précédent
- Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy
- Oluwadamilola H. Iwajomo, Peter Moons, Rose Nkhata, David Mzinza, Abiodun D. Ogunniyi, Neil A. Williams, Robert S. Heyderman, Adam Finn
- Cellular microRNA-miR-548g-3p modulates the replication of dengue virus
- Weitao Wen, Zhenjian He, Qinlong Jing, Yiwen Hu, Cuiji Lin, Rui Zhou, Xiaoqun Wang, Yangfan Su, Jiehao Yuan, Zhenxin Chen, Jie Yuan, Jueheng Wu, Jun Li, Xun Zhu, Mengfeng Li
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?